纤维囊性乳腺病患者补充ω-3脂肪酸和维生素E的代谢反应：一项随机、双盲、安慰剂对照试验
Metabolic Response to Omega-3 Fatty Acids and Vitamin E Co-Supplementation in Patients with Fibrocystic Breast Disease: A Randomized, Double-Blind, Placebo-Controlled Trial.
作者信息
Mirhashemi Seyyed Mehdi, Sahmani Mehdi, Salehi Behnaz, Zavar Reza Javad, Taghizadeh Mohsen, Moussavi Nushin, Badehnoosh Bita, Asemi Zatollah
机构信息
Clinical Biochemistry and Genetics Department, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.
Department of Clinical Biochemistry, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
出版信息
Arch Iran Med. 2017 Aug;20(8):466-473.
BACKGROUND
There is scarce data on the effects of omega-3 fatty acids and vitamin E co-supplementation on metabolic status in patients with fibrocystic breast disease (FBD). The current study was carried out to determine the effects of omega-3 fatty acids and vitamin E co-supplementation on metabolic status in patients with FBD.
METHODS
A randomized clinical trial was conducted on 56 patients with FBD. Participants were randomly divided into two groups to receive either 1000 mg omega-3 fatty acids plus 400 mg vitamin E (n = 28) or placebo (n = 28) for 12 weeks. Fasting blood samples were taken at the beginning of the study and after 12 weeks of intervention to determine inflammatory factors, biomarkers of oxidative stress, and metabolic profiles.
RESULTS
After 12 weeks of intervention, changes in serum high-sensitivity C-reactive protein (-2171.4 ± 3189.1 vs. +696.9 ± 2774.8 ng/mL, P = 0.001) and plasma nitric oxide (+1.8 ± 4.0 vs. -0.1 ± 2.4 µmol/L, P = 0.04) in supplemented women were significantly different from those in the placebo group. In addition, compared to the placebo group, subjects who consumed omega-3 fatty acids plus vitamin E supplements had significantly decreased serum insulin concentrations (-3.2 ± 6.5 vs. -0.2 ± 1.7 µIU/mL, P = 0.01), the homeostasis model of assessment-estimated insulin resistance (-0.8 ± 1.7 vs. -0.02 ± 0.4, P = 0.03), serum triglycerides levels (-11.5 ± 47.3 vs. +10.6 ± 24.3 mg/dL, P = 0.03) and VLDL-cholesterol (-2.3 ± 9.5 vs. +2.1 ± 4.9 mg/dL, P = 0.03), as well as increased quantitative insulin sensitivity check index (+0.01 ± 0.01 vs. +0.001 ± 0.007, P = 0.001) and HDL-cholesterol (+3.4 ± 6.0 vs. -1.3 ± 4.3 mg/dL, P = 0.001).
CONCLUSION
Overall, omega-3 fatty acids and vitamin E co-supplementation for 12 weeks had beneficial effects on inflammatory markers and metabolic profiles in patients with FBD.
背景
关于ω-3脂肪酸和维生素E联合补充对纤维囊性乳腺病（FBD）患者代谢状态影响的数据稀缺。本研究旨在确定ω-3脂肪酸和维生素E联合补充对FBD患者代谢状态的影响。
方法
对56例FBD患者进行了一项随机临床试验。参与者被随机分为两组，分别接受1000毫克ω-3脂肪酸加400毫克维生素E（n = 28）或安慰剂（n = 28），为期12周。在研究开始时和干预12周后采集空腹血样，以测定炎症因子、氧化应激生物标志物和代谢谱。
结果
干预12周后，补充组女性血清高敏C反应蛋白（-2171.4±3189.1对+696.9±2774.8纳克/毫升，P = 0.001）和血浆一氧化氮（+1.8±4.0对-0.1±2.4微摩尔/升，P = 0.04）的变化与安慰剂组有显著差异。此外，与安慰剂组相比，服用ω-3脂肪酸加维生素E补充剂的受试者血清胰岛素浓度显著降低（-3.2±6.5对-0.2±1.7微国际单位/毫升，P = 0.01）、稳态模型评估估计的胰岛素抵抗（-0.8±1.7对-0.02±0.4，P = 0.03）、血清甘油三酯水平（-11.5±47.3对+10.6±24.3毫克/分升，P = 0.03）和极低密度脂蛋白胆固醇（-2.3±9.5对+2.1±4.9毫克/分升，P = 0.03），以及定量胰岛素敏感性检查指数升高（+0.01±0.01对+0.001±0.007，P = 0.001）和高密度脂蛋白胆固醇升高（+3.4±6.0对-1.3±4.3毫克/分升，P = 0.001）。
结论
总体而言，ω-3脂肪酸和维生素E联合补充12周对FBD患者的炎症标志物和代谢谱有有益影响。
Zotero 插件