a Biopharming Research Unit, Department of Molecular & Cell Biology , University of Cape Town; Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town , Cape Town , South Africa.
Hum Vaccin Immunother. 2017 Dec 2;13(12):2912-2917. doi: 10.1080/21645515.2017.1356497. Epub 2017 Aug 28.
The One Health initiative is increasingly becoming a prominent discussion topic in animal and human health, with its focus on prevention of spread of zoonotic diseases, both in animals, and from animals to humans. An important part of One Health is that diagnostics and vaccines for diseases may be the same thing - and be used for both humans and animals. One potential problem standing in the way of wider adoption of One Health principles, though, is that use of conventional cell fermentation systems for production of the recombinant proteins that could be used as diagnostics or vaccines is often expensive and is not easily scalable. A solution to this may be the use of plants or plant cells as bioreactors: molecular farming, or the production of biologics in plants, is now a well-established science with many proofs of principle and important proofs of efficacy for especially animal vaccines. This review discusses how molecular farming could enable important advances in One Health, using as examples plant-made vacccines, reagents and therapeutics for influenza viruses, ebolaviruses, rabies virus, bunyaviruses and flaviviruses.
“同一健康”倡议越来越成为动物和人类健康领域的热门话题，其重点是预防人畜共患疾病的传播，包括在动物和从动物到人。“同一健康”的一个重要部分是，疾病的诊断和疫苗可能是一回事，并且可以同时用于人类和动物。然而，在更广泛地采用“同一健康”原则方面存在一个潜在问题，即使用传统的细胞发酵系统生产可作为诊断或疫苗的重组蛋白通常成本高昂且不易扩展。解决这个问题的方法可能是使用植物或植物细胞作为生物反应器：分子农业，或在植物中生产生物制剂，现在是一个成熟的科学，有许多原理证明，特别是对动物疫苗的功效证明。本文讨论了分子农业如何能够通过使用植物制造的流感病毒、埃博拉病毒、狂犬病病毒、布尼亚病毒和黄病毒疫苗、试剂和治疗药物等例子，在“同一健康”中实现重要进展。
