Mason G A, Walker C H, Prange A J, Bondy S C
Psychoneuroendocrinology. 1987;12(1):53-9. doi: 10.1016/0306-4530(87)90022-9.
Studies of the effects of thyroid hormones on the uptake of neurotransmitters by homogenates of rat cerebral cortex have revealed a significant competitive inhibition of neuronal uptake of [3H]GABA by thyroid hormones (T3 greater than T4 greater than rT3). The IC50 for inhibition of GABA uptake by T3 was estimated at 4 microM and that of T4 at 11 microns. GABA uptake in homogenates of cerebral cortex from hypothyroid rats was significantly enhanced over that of controls; however, uptake in tissues from hyperthyroid rats was not significantly diminished.
对甲状腺激素对大鼠大脑皮层匀浆摄取神经递质影响的研究表明，甲状腺激素（T3 > T4 > rT3）对神经元摄取[3H]GABA具有显著的竞争性抑制作用。T3抑制GABA摄取的IC50估计为4 microM，T4为11 microM。甲状腺功能减退大鼠大脑皮层匀浆中的GABA摄取比对照组显著增强；然而，甲状腺功能亢进大鼠组织中的摄取没有显著减少。
