Gupta Priya, Bhattacharjee Surajit, Sharma Ashish Ranjan, Sharma Garima, Lee Sang-Soo, Chakraborty Chiranjib
Department of Molecular Biology & Bioinformatics, Tripura University (A Central University), Suryamaninagar, Tripura-799022. India.
Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon 200704. Korea.
Curr Alzheimer Res. 2017;14(11):1198-1206. doi: 10.2174/1567205014666170829101016.
Alzheimer's disease is a neurodegenerative disorder which generally affects people who are more than 60 years of age. The disease is clinically characterised by dementia, loss of cognitive functions and massive neurodegeneration. The presence of neurofibrilary tangles and amyloid plaques in the hippocampal region of the brain are the hallmarks of the disease. Current therapeutic approaches for the treatment of Alzheimer's disease are symptomatic and disease modifying, none of which provide any permanent solution or cure for the disease. Dysregulation of miRNAs is one of the major causes of neurodegeneration.
In the present review, the roles of different miRNAs such as miR-9, miR-107, miR-29, miR-34, miR-181, miR-106, miR-146a, miR132, miR124a, miR153 has been discussed in detail in the pathogenesis of various neurodegenerative diseases with special focus on AD. The probability of miRNAs as an alternative and more sensitive approach for detection and management of the AD has also been discussed.
阿尔茨海默病是一种神经退行性疾病，通常影响60岁以上的人群。该疾病的临床特征为痴呆、认知功能丧失和大量神经退行性变。大脑海马区出现神经原纤维缠结和淀粉样斑块是该疾病的标志。目前治疗阿尔茨海默病的方法包括对症治疗和疾病修饰治疗，但均无法提供任何永久性解决方案或治愈该疾病。微小RNA（miRNA）失调是神经退行性变的主要原因之一。
在本综述中，详细讨论了不同miRNA，如miR-9、miR-107、miR-29、miR-34、miR-181、miR-106、miR-146a、miR132、miR124a、miR153在各种神经退行性疾病发病机制中的作用，特别关注了阿尔茨海默病。还讨论了将miRNA作为检测和管理阿尔茨海默病的替代且更敏感方法的可能性。
