Han Zhen, Zhang Lei, Ma Minhang, Keshavarzi Maryam
Department of Physical Education, Zhejiang International Studies University, Hangzhou, 310023, Zhejiang, China.
Institute of Physical Education and Sports, Capital University Of Physical Education And Sports, Beijing, 100191, China.
Mol Neurobiol. 2025 Jan;62(1):485-500. doi: 10.1007/s12035-024-04292-4. Epub 2024 Jun 13.
Recent research has exposed a growing body of proof underscoring the importance of microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) in maintaining the physical composition of neurons and influencing cognitive functioning in both standard and atypical circumstances. Extensive research has been conducted on the possible application of miRNAs and lncRNAs as biomarkers for various diseases, with a particular focus on brain disorders, as they possess remarkable durability in cell-free surroundings and can endure repeated freezing and thawing processes. It is intriguing to note that miRNAs and lncRNAs have the ability to function through paracrine mechanisms, thereby playing a role in communication between different organs. Recent research has proposed that the improvement of cognitive abilities through physical exercise in mentally healthy individuals is a valuable method for uncovering potential connections between miRNAs, or microRNAs, and lncRNAs, and human cognitive function. The process of cross-correlating data from disease models and patients with existing data will be crucial in identifying essential miRNAs and lncRNAs, which can potentially act as biomarkers or drug targets in the treatment of cognitive disorders. By combining this method with additional research in animal models, we can determine the function of these molecules and their potential impact on therapy. This article discusses the latest research about the primary miRNAs, lncRNAs, and their exosomes that are affected by physical activity in terms of human cognitive function.
最近的研究揭示了越来越多的证据，强调了微小RNA（miRNA）和长链非编码RNA（lncRNA）在维持神经元的物理组成以及在正常和非典型情况下影响认知功能方面的重要性。针对miRNA和lncRNA作为各种疾病生物标志物的可能应用，已经开展了广泛研究，尤其关注脑部疾病，因为它们在无细胞环境中具有显著的稳定性，并且能够经受反复的冻融过程。值得注意的是，miRNA和lncRNA能够通过旁分泌机制发挥作用，从而在不同器官之间的通讯中发挥作用。最近的研究表明，在心理健康的个体中通过体育锻炼提高认知能力，是揭示miRNA（即微小RNA）、lncRNA与人类认知功能之间潜在联系的一种有价值的方法。将疾病模型和患者的数据与现有数据进行交叉关联的过程，对于识别关键的miRNA和lncRNA至关重要，这些分子有可能在认知障碍的治疗中充当生物标志物或药物靶点。通过将这种方法与动物模型中的其他研究相结合，我们可以确定这些分子的功能及其对治疗的潜在影响。本文讨论了关于主要的miRNA、lncRNA及其外泌体在人类认知功能方面受体育活动影响的最新研究。
