College of Life Sciences, China JiLiang University, Hangzhou, Zhejiang, 310018, China.
College of Life Sciences, China JiLiang University, Hangzhou, Zhejiang, 310018, China.
Int J Biol Macromol. 2018 Jan;106:1139-1145. doi: 10.1016/j.ijbiomac.2017.08.118. Epub 2017 Aug 25.
The anti-diabetic effect of the Auricularia auricular polysaccharides simulated hydrolysates (APSHs) obtained from the dried fruiting body of Auricularia auricular was studied in this paper. The APSHs were administered intragastrically (i.g.) at the dose of 0.15g/kg b.w. to the streptozotocin (STZ) -induced diabetic male SD rats for 7 weeks. The results showed that fasting blood glucose level was significantly reduced (p<0.05), whereas the glucose tolerance was remarkable improvement in STZ-induced diabetic rats through APSHs administration, and loss in body weight was also prevented in diabetic mice (p<0.05). Moreover, APSHs could increase hepatic glycogen and pancreatic insulin level (p<0.01), as well as decrease the levels of serum TG and LDL-C compared to the diabetic control group (p<0.05). APSHs had no significant effects on the total cholesterol and HDL-C levels. APSHs were composed of arabinose, xylose, mannose, glucose, galactose and glucosamine with the molar ratio of 1.91:0.52:2.89:1.00:0.67:0.23. These studies suggest that APSHs exerts marked antidiabetic effect in experimental diabetes mellitus, thus justifying the potential treatment for diabetic mellitus.
本文研究了从银耳干燥子实体中获得的银耳多糖模拟水解物（APSHs）的抗糖尿病作用。将 APSHs 以 0.15g/kg b.w. 的剂量通过胃内给药（i.g.）给予链脲佐菌素（STZ）诱导的糖尿病雄性 SD 大鼠 7 周。结果表明，通过 APSHs 给药可显著降低空腹血糖水平（p<0.05），改善 STZ 诱导的糖尿病大鼠的葡萄糖耐量，并防止糖尿病小鼠体重下降（p<0.05）。此外，与糖尿病对照组相比，APSHs 可增加肝糖原和胰腺胰岛素水平（p<0.01），并降低血清 TG 和 LDL-C 水平（p<0.05）。APSHs 对总胆固醇和 HDL-C 水平没有显著影响。APSHs 由阿拉伯糖、木糖、甘露糖、葡萄糖、半乳糖和氨基葡萄糖组成，摩尔比为 1.91:0.52:2.89:1.00:0.67:0.23。这些研究表明，APSHs 在实验性糖尿病中表现出明显的抗糖尿病作用，因此为糖尿病的潜在治疗提供了依据。
