Xu Wei, Zhou Qing, Yin Jiao-jiao, Yao Yong, Zhang Jiu-liang
College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Department of Pharmacy, Wuhan City Central Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China.
Int J Biol Macromol. 2015 Jan;72:575-9. doi: 10.1016/j.ijbiomac.2014.09.011. Epub 2014 Sep 16.
The present study evaluated the anti-diabetic effects of the polysaccharides obtained from Talinum triangulare (TTP). Two TTP doses (150 mg/kg and 300 mg/kg · bw/d) were administered orally to normal and streptozotocin (STZ)-induced type 2 diabetic male Kunming mice, respectively. The TTP hypoglycemic and hypolipidemic effects were evaluated by testing the fast blood glucose (FBG) level, fasting serum insulin (FINS), and serum lipids (TC, TG, HDL, LDL) as well as the body, hepar and kidney weights. After four weeks administration, the low-dose group 150 mg/kg · bw/d) and high-dose group (300 mg/kg · bw/d) showed a marked FBG fall rate of 29.85% and 41.18% (FBG fall rate% = ((Diabetic control--TTP group)/Diabetic control) × 100%). The results of FBG and serum lipids indicate that TTP possess significant hypoglycemic effect, but no significant hypolipidemic effect. These results suggest the potential use of TTP as a functional food for the treatment of type 2 diabetic mellitus (T2DM).
本研究评估了三角叶西番莲多糖（TTP）的抗糖尿病作用。分别以两种剂量（150毫克/千克和300毫克/千克·体重/天）将TTP口服给予正常雄性昆明小鼠和链脲佐菌素（STZ）诱导的2型糖尿病雄性昆明小鼠。通过检测空腹血糖（FBG）水平、空腹血清胰岛素（FINS）、血脂（总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白）以及体重、肝脏和肾脏重量来评估TTP的降血糖和降血脂作用。给药四周后，低剂量组（150毫克/千克·体重/天）和高剂量组（300毫克/千克·体重/天）的FBG下降率分别为29.85%和41.18%（FBG下降率% = [（糖尿病对照组 - TTP组）/糖尿病对照组]×100%）。FBG和血脂结果表明，TTP具有显著的降血糖作用，但无显著的降血脂作用。这些结果提示TTP作为治疗2型糖尿病（T2DM）功能性食品的潜在用途。
