Institute of Agricultural Resources and Environment, Shandong Academy of Agricultural Science, Key Laboratory of Wastes Matrix Utilization, Ministry of Agriculture, Jinan 250100, China.
College of Life Science, Shandong Agricultural University, Tai'an 271018, China.
Oxid Med Cell Longev. 2018 Nov 25;2018:9150807. doi: 10.1155/2018/9150807. eCollection 2018.
The present work was performed to evaluate the effect of acidic-extractable polysaccharides (AE-PS) from fruit bodies of on type 2 diabetes mellitus (T2DM) and its structural characteristics. The T2DM mice induced by high-fat diet (HFD) and streptozotocin (STZ) were administered with 100 and 400 mg/kg AE-PS for 4 weeks. Our work proved that AE-PS decreased the levels of serum lipid, lipid peroxidation, and blood glucose; improved glucose and insulin resistance; enhanced antioxidant enzyme activities; and attenuated the injuries of the liver, kidney, and pancreas in T2DM mice. These results might offer references for the exploitation of AE-PS as functional foods or natural drug source for preventing and treating HFD- and STZ-induced T2DM. Moreover, gas chromatography (GC) results revealed that AE-PS was heterogeneous and composed of fucose, ribose, arabinose, xylose, mannose, galactose, and glucose with mass percentages of 1.23%, 0.57%, 0.29%, 2.12%, 2.73%, 4.66%, and 88.4%, respectively. Fourier-transform infrared (FTIR) and nuclear magnetic resonance (NMR) analysis indicated that AE-PS was a pyran-type polysaccharide with - and -configurations.
本研究旨在评估来源于担子菌果实体的酸性可提取多糖（AE-PS）对 2 型糖尿病（T2DM）的影响及其结构特征。采用高脂饮食（HFD）和链脲佐菌素（STZ）诱导 T2DM 小鼠，分别给予 100 和 400mg/kg AE-PS 治疗 4 周。研究结果表明，AE-PS 可降低血清脂质、脂质过氧化和血糖水平，改善葡萄糖和胰岛素抵抗，增强抗氧化酶活性，并减轻 T2DM 小鼠肝、肾和胰腺的损伤。这些结果可能为开发 AE-PS 作为预防和治疗 HFD 和 STZ 诱导的 T2DM 的功能性食品或天然药物来源提供参考。此外，气相色谱（GC）结果表明，AE-PS 是一种不均一的多糖，由岩藻糖、核糖、阿拉伯糖、木糖、甘露糖、半乳糖和葡萄糖组成，其质量百分比分别为 1.23%、0.57%、0.29%、2.12%、2.73%、4.66%和 88.4%。傅里叶变换红外（FTIR）和核磁共振（NMR）分析表明，AE-PS 是一种吡喃型多糖，具有-α和-β构型。
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