Kay P H, Dawkins R L, Bowling A T, Bernoco D
Vet Rec. 1987 Apr 11;120(15):363-5. doi: 10.1136/vr.120.15.363.
A cDNA probe to the alpha subunit of the murine acetylcholine receptor was used to demonstrate restriction fragment length polymorphism in an acetylcholine receptor gene in the horse. Three different patterns of polymorphism have been observed with fragment sizes of 4.3 and 2.9 kilobases (kb) (pattern 1), 4.3 and 2.5 kb (pattern 2) and 4.3, 2.9 and 2.5 kb (pattern 1,2). Analysis of a three generation pedigree has suggested that patterns 1 and 2 represent two allelic forms of the gene encoding the alpha subunit of the acetylcholine receptor. These data provide a basis for the examination of the genetic control of neuromuscular function in the horse.
用小鼠乙酰胆碱受体α亚基的cDNA探针来证明马的乙酰胆碱受体基因存在限制性片段长度多态性。观察到三种不同的多态性模式，片段大小分别为4.3和2.9千碱基（kb）（模式1）、4.3和2.5 kb（模式2）以及4.3、2.9和2.5 kb（模式1,2）。对一个三代家系的分析表明，模式1和模式2代表了编码乙酰胆碱受体α亚基的基因的两种等位基因形式。这些数据为研究马神经肌肉功能的遗传控制提供了基础。
