Key State Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; Institute of Genetics and Developmental Biology, International College, University of Chinese Academy of Science, Beijing 100101, China.
Non-Communicable Disease Research Unit, South African Medical Research Council and University of Cape Town, Cape Town, South Africa.
Pharmacol Res. 2018 Feb;128:130-136. doi: 10.1016/j.phrs.2017.08.011. Epub 2017 Aug 25.
The aim of this systematic review and meta-analysis of prospective interventional studies was to investigate the effects of coenzyme Q10 (CQ10) on plasma C-reactive protein (CRP) levels. PubMed/Medline, Web of Science (WoS), Cochrane Database and Google Scholar databases were searched (up to December 2016) to identify prospective studies evaluating the impact of CQ10 supplementation on CRP. Random effects models meta-analysis was used for quantitative data synthesis. Sensitivity analysis used the leave-one-out method, and heterogeneity was quantitatively assessed using the I index. Systematic review PROSPERO database registration: CRD42016038155. From a total of 119 entries identified via searches, 7 studies were finally included to the analysis. The results of the meta-analysis indicated a non-significant reduction in CRP concentrations following supplementation with CQ10 with a weighted mean difference [WMD] of -0.25mg/l (95% confidence intervals [CI] -0.56 to 0.06, I=42.0%). The WMD for the effects on interleukin 6 (IL6) was -0.72pg/dl, (95% CI -1.24 to -0.24, I=51.8%). These findings were robust in sensitivity analyses. Random-effects meta-regression revealed that changes in plasma CRP levels were independent of the dosage of CQ10 (slope: -0.0005; 95% CI: -0.005, 0.004; p=0.832) while duration of supplementation was the dependent mediator (slope: slope: -0.111; 95% CI: -0.21, -0.004; p=0.042). In conclusion, CQ10 supplementation has a borderline favourable effect on CRP levels, and a significant effect on IL-6 level. This suggests that CQ10 supplementation likely attenuates subclinical inflammation.
本系统评价和前瞻性干预研究的荟萃分析旨在探讨辅酶 Q10（CQ10）对血浆 C 反应蛋白（CRP）水平的影响。通过检索 PubMed/Medline、Web of Science（WoS）、Cochrane 数据库和 Google Scholar 数据库（截至 2016 年 12 月），以确定评估 CQ10 补充对 CRP 影响的前瞻性研究。采用随机效应模型荟萃分析进行定量数据合成。敏感性分析采用逐一剔除法，使用 I 指数定量评估异质性。系统评价 PROSPERO 数据库注册：CRD42016038155。通过检索共确定了 119 项研究，最终有 7 项研究纳入分析。荟萃分析结果表明，CQ10 补充后 CRP 浓度无显著降低，加权均数差（WMD）为-0.25mg/l（95%置信区间[CI] -0.56 至 0.06，I=42.0%）。对白细胞介素 6（IL6）的影响的 WMD 为-0.72pg/dl（95%CI-1.24 至-0.24，I=51.8%）。这些发现通过敏感性分析得到验证。随机效应荟萃回归表明，血浆 CRP 水平的变化与 CQ10 的剂量无关（斜率：-0.0005；95%CI：-0.005，0.004；p=0.832），而补充时间是依赖性中介物（斜率：-0.111；95%CI：-0.21，-0.004；p=0.042）。总之，CQ10 补充对 CRP 水平具有边缘有利的影响，对 IL-6 水平有显著影响。这表明 CQ10 补充可能减轻亚临床炎症。
