辅酶Q10补充剂对炎症和氧化应激生物标志物的缓解作用：一项汇总荟萃分析的结果

Alleviating effects of coenzyme Q10 supplements on biomarkers of inflammation and oxidative stress: results from an umbrella meta-analysis.

作者信息

Dabbaghi Varnousfaderani Sara, Musazadeh Vali, Ghalichi Faezeh, Kavyani Zeynab, Razmjouei Soha, Faghfouri Amir Hossein, Ahrabi Sana Sedgh, Seyyed Shoura Seyyed Morteza, Dehghan Parvin

机构信息

Department of Pharmacy, Shahid Beheshti University of Medical Science, Tehran, Iran.

Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.

出版信息

Front Pharmacol. 2023 Aug 8;14:1191290. doi: 10.3389/fphar.2023.1191290. eCollection 2023.

Although several meta-analyses support the positive effect of coenzyme Q10 (CoQ10) on biomarkers of oxidative stress and inflammation, the results of some other studies reject such effects. Therefore, in this umbrella meta-analysis, we performed a comprehensive systematic search in such databases as Web of Science, PubMed, Scopus, Embase, and Google Scholar up to January 2023. Based on standardized mean difference analysis, CoQ10 supplementation significantly decreased serum C-reactive protein (CRP) (ES = -0.39; 95% CI: 0.77, -0.01, = 0.042) and malondialdehyde (MDA) (ES = -1.17; 95% CI: 1.55, -0.79, < 0.001), while it increased the total antioxidant capacity (TAC) (ES = 1.21; 95% CI: 0.61, 1.81, < 0.001) and serum superoxide dismutase (SOD) activity (ES = 1.08; 95% CI: 0.37, 1.79, = 0.003). However, CoQ10 supplementation had no significant reducing effect on tumor-necrosis factor-alpha (TNF- α) (ES = -0.70; 95% CI: 2.09, 0.68, = 0.320) and interleukin-6 (IL-6) levels (ES = -0.85; 95% CI: 1.71, 0.01, = 0.053). Based on weighted mean difference analysis, CoQ10 supplementation considerably decreased TNF-α (ES = -0.46, 95% CI: 0.65, -0.27; < 0.001), IL-6 (ES = -0.92, 95% CI: 1.40, -0.45; < 0.001), and CRP levels (effect sizes = -0.28, 95% CI: 0.47, -0.09; < 0.001). The results of our meta-analysis supported the alleviating effects of CoQ10 on markers of inflammation cautiously. However, CoQ10 had antioxidant effects regarding the improvement of all the studied antioxidant and oxidative stress biomarkers. https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=323861, identifier CRD42022323861.

尽管多项荟萃分析支持辅酶Q10（CoQ10）对氧化应激和炎症生物标志物具有积极作用，但其他一些研究结果却否定了这种作用。因此，在这项伞状荟萃分析中，截至2023年1月，我们在Web of Science、PubMed、Scopus、Embase和谷歌学术等数据库中进行了全面的系统检索。基于标准化均值差分析，补充CoQ10可显著降低血清C反应蛋白（CRP）（效应量ES = -0.39；95%置信区间：0.77，-0.01，P = 0.042）和丙二醛（MDA）（ES = -1.17；95%置信区间：1.55，-0.79，P < 0.001），同时提高总抗氧化能力（TAC）（ES = 1.21；95%置信区间：0.61，1.81，P < 0.001）和血清超氧化物歧化酶（SOD）活性（ES = 1.08；95%置信区间：0.37，1.79，P = 0.003）。然而，补充CoQ10对肿瘤坏死因子-α（TNF-α）（ES = -0.70；95%置信区间：2.09，0.68，P = 0.320）和白细胞介素-6（IL-6）水平（ES = -0.85；95%置信区间：1.71，0.01，P = 0.053）没有显著降低作用。基于加权均值差分析，补充CoQ10可显著降低TNF-α（ES = -0.46，95%置信区间：0.65，-0.27；P < 0.001）、IL-6（ES = -0.92，95%置信区间：1.40，-0.45；P < 0.001）和CRP水平（效应量ES = -0.28，95%置信区间：0.47，-0.09；P < 0.001）。我们的荟萃分析结果谨慎地支持了CoQ10对炎症标志物的缓解作用。然而，CoQ10在改善所有研究的抗氧化和氧化应激生物标志物方面具有抗氧化作用。https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=323861，标识符CRD42022323861 。