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卢立康唑、拉康唑和依氟康唑与五种抗真菌药物对黑化真菌及其亲缘种的活性比较。

Activities of Luliconazole, Lanoconazole, and Efinaconazole Compared with Those of Five Antifungal Drugs against Melanized Fungi and Relatives.

机构信息

Department of Medical Parasitology and Mycology, School of Public Health, National Institute of Health Research, Tehran University of Medical Sciences, Tehran, Iran.

Department of Medical Mycology and Parasitology, Invasive Fungi Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

出版信息

Antimicrob Agents Chemother. 2017 Oct 24;61(11). doi: 10.1128/AAC.00635-17. Print 2017 Nov.

DOI:10.1128/AAC.00635-17
PMID:28848012
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5655049/
Abstract

The activities of novel azoles compared to those of five antifungal drugs against clinical ( = 28) and environmental ( = 102) isolates of black mold and melanized yeast were determined. Luliconazole and lanoconazole had the lowest geometric mean MICs, followed by efinaconazole, against tested isolates compared to the other drugs. Therefore, it appears that these new imidazole and triazole drugs are promising candidates for the treatment of infections due to melanized fungi and their relatives.

摘要

测定了新型唑类药物与五种抗真菌药物对临床（=28）和环境（=102）黑曲霉和黑化酵母分离株的活性。与其他药物相比，卢立康唑和拉诺康唑对测试分离株的几何平均 MIC 最低，其次是依非康唑。因此，这些新型咪唑和三唑类药物似乎是治疗由黑化真菌及其亲缘种引起的感染的有希望的候选药物。

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J Clin Microbiol. 2017 Apr;55(4):1090-1103. doi: 10.1128/JCM.02413-16. Epub 2017 Jan 18.
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Potent Activities of Novel Imidazoles Lanoconazole and Luliconazole against a Collection of Azole-Resistant and -Susceptible Aspergillus fumigatus Strains.新型咪唑类药物兰诺康唑和卢立康唑对一系列唑类耐药和敏感烟曲霉菌株的强效活性
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Dematiaceous Molds.暗色真菌
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Black Molds and Melanized Yeasts Pathogenic to Humans.对人类致病的黑色霉菌和黑化酵母。
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