Feet P O, Larsen S, Lillevold P E, Liden A, Holm V, Robak O H
Acta Psychiatr Scand. 1987 Apr;75(4):435-40. doi: 10.1111/j.1600-0447.1987.tb02812.x.
Sixty-three non-agitated depressed out-patients were selected according to the Feighner-Robins-Guze criteria for primary depressions for a double-blind, between-patient randomized study for an 8 week duration. All the patients were treated with imipramine following a fixed dose schedule for the first 2 weeks and thereafter according to clinical response (100-200 mg/day). This treatment was combined with either placebo, diazepam (10 mg/day) or dixyrazine (50 mg/day). The serum concentration of imipramine both at 2 weeks and later was significantly higher (P less than 0.05) in the group treated with dixyrazine than in the other two groups. In the group treated with diazepam, the serum levels of imipramine and desipramine were significantly lower than in the placebo group. The serum concentrations of diazepam, desmethyldiazepam and dixyrazine were almost unchanged during the study. No significant correlation was found between the dosage and the serum concentration of imipramine or desipramine. The change in mean CPRS-score correlated neither with the imipramine nor with the desipramine serum levels, it did correlate but negatively with the degree of side effects. The degree of side effects correlated positively with the serum concentration of desipramine.
根据费伊纳-罗宾斯-古泽原发性抑郁症标准，选取63例无躁狂症状的门诊抑郁症患者，进行为期8周的双盲、患者间随机研究。所有患者在最初2周按照固定剂量方案接受丙咪嗪治疗，之后根据临床反应调整剂量（100 - 200毫克/天）。该治疗与安慰剂、地西泮（10毫克/天）或二苯拉嗪（50毫克/天）联合使用。接受二苯拉嗪治疗的组在2周及之后的丙咪嗪血清浓度显著高于其他两组（P小于0.05）。在地西泮治疗组中，丙咪嗪和去甲丙咪嗪的血清水平显著低于安慰剂组。在研究期间，地西泮、去甲基地西泮和二苯拉嗪的血清浓度几乎没有变化。未发现丙咪嗪或去甲丙咪嗪的剂量与血清浓度之间存在显著相关性。CPRS评分的变化与丙咪嗪或去甲丙咪嗪的血清水平均无相关性，但与副作用程度呈负相关。副作用程度与去甲丙咪嗪的血清浓度呈正相关。
