Departments of Neurology, Seoul National University School of Medicine, Seoul National University Bundang Hospital, Bundang, Republic of Korea.
Neurodegener Dis. 2017;17(6):276-280. doi: 10.1159/000479111. Epub 2017 Aug 25.
BACKGROUND/AIMS: Gender differences of health-related quality of life (HRQoL) in patients with various disorders have been reported. Various nonmotor symptoms (NMSs) also affect the patients' lives and HRQoL, even in the early stages of Parkinson disease (PD). Our study aimed to identify whether there are gender differences of HRQoL in PD patients in the early stages, and which NMSs are associated with HRQoL depending on gender.
Eighty-nine PD patients (47 males, 42 females) and 36 healthy controls were enrolled. We evaluated HRQoL, NMSs, and their associations in each gender.
The total Parkinson Disease Quality of Life Questionnaire and Beck Anxiety Inventory scores were higher in female patients than in male patients. The correlation analysis revealed no association between NMSs and HRQoL in male patients. In female patients, HRQoL was highly correlated with depression, and moderately associated with fatigue.
Gender differences of an association between HRQoL and NMSs exist in PD. We found that fatigue and depression were the main determinants of poor HRQoL in female patients even in the early stages. We suggest that a gender-specific therapeutic approach is important, and it is necessary to pay special attention to the predictors associated with causing poor HRQoL.
背景/目的：已有研究报道，不同疾病患者的健康相关生活质量（HRQoL）存在性别差异。各种非运动症状（NMSs）也会影响患者的生活和 HRQoL，即使在帕金森病（PD）的早期阶段也是如此。我们的研究旨在确定早期 PD 患者的 HRQoL 是否存在性别差异，以及哪些 NMSs 与性别相关的 HRQoL 有关。
共纳入 89 名 PD 患者（47 名男性，42 名女性）和 36 名健康对照者。我们评估了每个性别中的 HRQoL、NMSs 及其相关性。
女性患者的帕金森病生活质量问卷总评分和贝克焦虑量表评分均高于男性患者。相关分析显示，男性患者的 NMSs 与 HRQoL 之间无相关性。在女性患者中，HRQoL 与抑郁高度相关，与疲劳中度相关。
PD 患者的 HRQoL 与 NMSs 之间存在性别差异。我们发现，即使在早期阶段，疲劳和抑郁也是导致女性患者 HRQoL 较差的主要决定因素。我们建议采用针对特定性别的治疗方法，有必要特别关注与导致 HRQoL 较差相关的预测因素。
