Hume Peter J, Singh Vikash, Davidson Anthony C, Koronakis Vassilis
Department of Pathology, University of CambridgeCambridge, United Kingdom.
Front Cell Infect Microbiol. 2017 Aug 9;7:348. doi: 10.3389/fcimb.2017.00348. eCollection 2017.
causes disease in humans and animals ranging from mild self-limiting gastroenteritis to potentially life-threatening typhoid fever. Salmonellosis remains a considerable cause of morbidity and mortality globally, and hence imposes a huge socio-economic burden worldwide. A key property of all pathogenic strains is the ability to invade non-phagocytic host cells. The major determinant of this invasiveness is a Type 3 Secretion System (T3SS), a molecular syringe that injects virulence effector proteins directly into target host cells. These effectors cooperatively manipulate multiple host cell signaling pathways to drive pathogen internalization. does not only rely on these injected effectors, but also uses several other T3SS-independent mechanisms to gain entry into host cells. This review summarizes our current understanding of the methods used by for cell invasion, with a focus on the host signaling networks that must be coordinately exploited for the pathogen to achieve its goal.
它可导致人类和动物患病，症状从轻微的自限性肠胃炎到可能危及生命的伤寒热不等。沙门氏菌病仍是全球发病和死亡的一个重要原因，因此在全球范围内造成了巨大的社会经济负担。所有致病菌株的一个关键特性是能够侵入非吞噬性宿主细胞。这种侵袭性的主要决定因素是III型分泌系统（T3SS），它是一种分子注射器，可将毒力效应蛋白直接注入靶宿主细胞。这些效应蛋白协同操纵多个宿主细胞信号通路以驱动病原体内化。它不仅依赖于这些注入的效应蛋白，还使用其他几种不依赖T3SS的机制进入宿主细胞。本综述总结了我们目前对其用于细胞侵袭的方法的理解，重点关注病原体为实现其目标而必须协同利用的宿主信号网络。
