Carvalhana Sofia, Oliveira Ana, Ferreira Pedro, Resende Margarida, Perdigoto Rui, Barroso Eduardo
Gastroenterology and Hepatology Department, Hospital de Santa Maria, Centro Hospitalar de Lisboa Norte, Lisbon, Portugal.
Intensive Care Unit, Hospital Curry Cabral, Centro Hospitalar de Lisboa Central, Lisbon, Portugal.
GE Port J Gastroenterol. 2017 Jan;24(1):40-42. doi: 10.1159/000450878. Epub 2016 Nov 16.
Most antidepressant agents have the potential to cause liver injury, even at therapeutic doses. Nevertheless, drug-induced liver injury (DILI) from antidepressant agents is a rare event. There is no way to prevent idiopathic DILI, but the severity of the reaction may be minimized with prompt recognition and early withdrawal of the agent. We describe a rare case of a 63-year-old man presenting with acute liver failure after 3 months of trazodone and diazepam administration at normal therapeutic doses, requiring liver transplantation. This report should increase physicians' awareness of this complication and call attention to the regular monitoring of liver tests in patients taking trazodone, in order to prevent life-threatening complications.
大多数抗抑郁药即便在治疗剂量下也有可能导致肝损伤。然而，抗抑郁药引起的药物性肝损伤（DILI）是罕见事件。特发性DILI无法预防，但通过迅速识别并尽早停用药物，可将反应的严重程度降至最低。我们描述了一例罕见病例，一名63岁男性在以正常治疗剂量服用曲唑酮和地西泮3个月后出现急性肝衰竭，需要进行肝移植。本报告应提高医生对这种并发症的认识，并提醒注意对服用曲唑酮的患者定期监测肝功能，以预防危及生命的并发症。
