Detry O, Delwaide J, De Roover A, Hans M F, Delbouille M H, Monard J, Honoré P
Department of Abdominal Surgery and Transplantation, CHU de Liège, University of Liège, Sart Tilman B35, B4000 Liège, Belgium.
Transplant Proc. 2009 Oct;41(8):3435-6. doi: 10.1016/j.transproceed.2009.09.022.
Although acute hepatitis may be a side effect of many medications, most cases are reversible after treatment interruption, and fulminant hepatic failure (FHF) is rare. Venlafaxine and trazodone are 2 popular antidepressant agents. Alteration of liver enzyme levels has been reported as a side effect of these drugs at normal doses. Herein we have reported the case of a 48-year-old woman without any previous history of liver disease, who developed fulminant liver failure after 4 months of venlafaxine and trazodone therapy. She required liver transplantation, a procedure that was successful with full patient recovery. The first 5 years of follow-up were uneventful. This case documented that venlafaxine and trazodone at normal doses can produce severe liver toxicity. Liver tests should be monitored regularly in patients who receive this therapy.
虽然急性肝炎可能是许多药物的副作用，但大多数病例在中断治疗后是可逆的，且暴发性肝衰竭（FHF）很少见。文拉法辛和曲唑酮是两种常用的抗抑郁药。有报道称，正常剂量使用这些药物会出现肝酶水平改变的副作用。在此，我们报告了一例48岁女性病例，该女性既往无肝病病史，在接受文拉法辛和曲唑酮治疗4个月后发生了暴发性肝衰竭。她需要进行肝移植，手术成功，患者完全康复。随访的前5年情况平稳。该病例证明正常剂量的文拉法辛和曲唑酮可产生严重的肝毒性。接受该治疗的患者应定期监测肝功能检查。
