Sogbetun Folarin, Eschenbacher Wlliam L, Welge Jeffrey A, Panos Ralph J
Division of Pulmonary, Critical Care, and Sleep Medicine, Cincinnati, Veterans Affairs Medical Center Cincinnati, Ohio.
Division of Pulmonary, Critical Care, and Sleep Medicine, Cincinnati, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Chronic Obstr Pulm Dis. 2016 Aug 3;3(4):705-715. doi: 10.15326/jcopdf.3.4.2016.0128.
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality within the Veterans Healthcare Administration (VHA) and is frequently under-diagnosed. We developed the Veterans Airflow Screening Questionnaire (VAFOSQ) to improve the identification of Veterans with airflow obstruction (AFO), the most commonly used criterion for the diagnosis of COPD.We created an initial survey with 78 variables that have been associated with AFO. A total of 825 patients in 3 primary care clinics performed spirometry after bronchodilator administration and completed the initial survey. Best sets regression was used to build a model that predicted AFO optimally. A total of 195 of 825 (23.3%) patients had AFO and 7 items positively predicted AFO. When the questionnaire score was greater than 25, the VAFOSQ accurately identified AFO with an area under the receiver operating curve of 0.72. In a prospective validation cohort of 376 participants, the positive predictive value was 32% and negative predictive value 81%. The VAFOSQ is a reliable and valid instrument for the identification of veterans at risk for AFO who would benefit from further evaluation with spirometry and assessment for COPD. The VAFOSQ is straightforward to use and can be easily self-administered and self-scored enabling widespread application within the VHA.
慢性阻塞性肺疾病(COPD)是退伍军人医疗管理局(VHA)中发病和死亡的主要原因,且经常被漏诊。我们开发了退伍军人气流筛查问卷(VAFOSQ),以改善对气流阻塞(AFO)退伍军人的识别,AFO是诊断COPD最常用的标准。我们创建了一个包含78个与AFO相关变量的初始调查问卷。3家初级保健诊所的825名患者在使用支气管扩张剂后进行了肺活量测定,并完成了初始调查。使用最佳子集回归建立了一个能最佳预测AFO的模型。825名患者中有195名(23.3%)患有AFO,7个项目能正向预测AFO。当问卷得分大于25分时,VAFOSQ在受试者工作特征曲线下面积为0.72时能准确识别AFO。在一个由376名参与者组成的前瞻性验证队列中,阳性预测值为32%,阴性预测值为81%。VAFOSQ是一种可靠且有效的工具,可用于识别有AFO风险的退伍军人,这些退伍军人将受益于进一步的肺活量测定评估和COPD评估。VAFOSQ使用简单,可轻松自行填写和计分,便于在VHA中广泛应用。