Smith C L, Hunter J M, Jones R S
Anaesthesia. 1987 Apr;42(4):387-93. doi: 10.1111/j.1365-2044.1987.tb03980.x.
The use of an infusion of vecuronium is described in seven patients with renal and respiratory failure in an intensive therapy unit. Neuromuscular function was monitored throughout using the train-of-four twitch technique. A bolus dose of vecuronium (0.1 mg/kg) was given, followed immediately by a continuous infusion (0.05 mg/kg/hour). The infusion rate was adjusted until the first twitch of the train was below 20% of control and then run at a constant rate. There was a marked variation in the dose of vecuronium administered (0.01-0.065 mg/kg/hour [corrected]). Two patients, who appeared to be most sensitive to the drug, were both receiving metronidazole. Recovery of neuromuscular function was extremely prolonged and widely variable (6-37 hours) on stopping the infusion. No adverse cardiovascular effects or evidence of histamine release were seen as a result of administration of the drug. Vecuronium is probably more suitable for administration in bolus doses rather than by infusion in patients with renal and respiratory failure.
在一家重症监护病房中，对7例伴有肾衰和呼吸衰竭的患者使用了维库溴铵静脉输注法。全程采用四个成串刺激技术监测神经肌肉功能。先给予维库溴铵单次剂量（0.1mg/kg），随后立即进行持续输注（0.05mg/kg/小时）。调整输注速率直至四个成串刺激中的第一个刺激低于对照值的20%，然后以恒定速率维持。所给予的维库溴铵剂量存在显著差异（0.01 - 0.065mg/kg/小时[校正后]）。有两名患者似乎对该药物最为敏感，他们当时都在接受甲硝唑治疗。停止输注后，神经肌肉功能的恢复极其延长且差异很大（6 - 37小时）。使用该药物未观察到不良心血管效应或组胺释放的证据。对于伴有肾衰和呼吸衰竭的患者，维库溴铵可能更适合单次给药而非静脉输注。
