National Engineering Research Center for Nano-Medicine, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.
Nanoscale. 2017 Sep 14;9(35):13095-13103. doi: 10.1039/c7nr03944a.
We present a total tissue engineered (TE) intervertebral disc (IVD) to address IVD degradation, which is a major cause of chronic neck and back pain. The TE IVD is comprised of an alginate hydrogel-based nucleus pulposus (NP) and hierarchically organized, concentric ring-aligned electrospun (ES) polycaprolactone (PCL)/poly (d,l-lactide-co-glycolide) (PLGA)/Collagen type I (PPC)-based annulus fibrosus (AF). The TE IVD exhibits excellent hydrophilicity to simulate highly hydrated native IVD. Long-term in vivo implantation assays demonstrate the excellent structural (shape maintenance, hydration, and integration with surrounding tissues) and functional (mechanical supporting and flexibility) performances of the TE IVD. Our study provides a novel approach for treating IVD degeneration.
我们提出了一种整体组织工程（TE）椎间盘（IVD），以解决 IVD 退化的问题，这是慢性颈背部疼痛的主要原因。TE IVD 由藻酸盐水凝胶为基础的髓核（NP）和分层组织的、同心环排列的静电纺丝（ES）聚己内酯（PCL）/聚（D，L-乳酸-co-乙醇酸）（PLGA）/I 型胶原蛋白（PPC）为基础的纤维环（AF）组成。TE IVD 表现出优异的亲水性，以模拟高度水合的天然 IVD。长期的体内植入试验证明了 TE IVD 的优异的结构（形状维持、水合和与周围组织的整合）和功能（机械支撑和灵活性）性能。我们的研究为治疗 IVD 退化提供了一种新的方法。
