Laboratory of Molecular Oncology, Department of Science and Technology, Quilmes National University, Bernal B1876BXD, Buenos Aires, Argentina.
Int J Oncol. 2017 Oct;51(4):1025-1034. doi: 10.3892/ijo.2017.4093. Epub 2017 Aug 9.
Rho GTPases are key molecular switches controlling the transduction of external signals to cytoplasmic and nuclear effectors. In the last few years, the development of genetic and pharmacological tools has allowed a more precise definition of the specific roles of Rho GTPases in cancer. The aim of the present review is to describe the cellular functions regulated by these proteins with focus in deregulated signals present in malignant tumors. Finally, we describe the state of the art in search of different experimental therapeutic strategies with Rho GTPases as molecular targets.
Rho GTPases 是控制外部信号向细胞质和核效应物转导的关键分子开关。在过去的几年中，遗传和药理学工具的发展使得 Rho GTPases 在癌症中的特定作用能够得到更精确的定义。本文的目的是描述这些蛋白调节的细胞功能，并重点介绍恶性肿瘤中存在的失调信号。最后，我们描述了 Rho GTPases 作为分子靶点的不同实验治疗策略的研究现状。
