Department of Neurology, Tianjin Huanhu Hospital, Tianjin Key Laboratory of Cerebral Vessels and Neural Degeneration, Tianjin 300350, P.R. China.
Department of Clinical Laboratory, Tianjin Huanhu Hospital, Tianjin Key Laboratory of Cerebral Vessels and Neural Degeneration, Tianjin 300350, P.R. China.
Mol Med Rep. 2017 Oct;16(4):5413-5417. doi: 10.3892/mmr.2017.7227. Epub 2017 Aug 11.
Currently, cerebral infarction (CI) is the leading cause of disability and the second leading cause of mortality in China, seriously affecting patient quality of life. Ischemia (IS) is considered to be the early stage of CI. The present study aims to investigate the variation of intestinal microbial communities in patients with CI and IS using high throughput sequencing technology, and then analyze the results to identify a novel potential pathogenic mechanism of CI and IS. In total, 8 patients with CI, 2 patients with IS and 10 healthy volunteers as a control were selected. Throughput sequencing technology was used to analyze the character and microbial population of the gut. The abundance of Escherichia, Bacteroides, Megamonas, Parabacteroides, Akkermansia, Prevotella, Faecalibacterium, Dialister, Bifidobacterium and Ruminococcus was the significant difference in the intestinal microbial communities of the CI and IS patients compared with the healthy group. It was also observed that CI and IS were closely associated with internal glucose metabolism. The intestinal gut disturbance of CI patients may be one of the causes inducing CI by glucose metabolism and maybe considered as a potential method to predict the disease.
目前，脑梗死（CI）是中国导致残疾和死亡的主要原因，严重影响患者的生活质量。缺血（IS）被认为是 CI 的早期阶段。本研究旨在通过高通量测序技术研究 CI 和 IS 患者肠道微生物群落的变化，然后分析结果，以确定 CI 和 IS 的一种新的潜在发病机制。共选择 8 例 CI 患者、2 例 IS 患者和 10 例健康志愿者作为对照。通过高通量测序技术分析肠道的特征和微生物种群。与健康组相比，CI 和 IS 患者肠道微生物群落中大肠杆菌、拟杆菌、巨单胞菌、副拟杆菌、阿克曼氏菌、普雷沃氏菌、粪杆菌、粪球菌、双歧杆菌和瘤胃球菌的丰度存在显著差异。还观察到 CI 和 IS 与内部葡萄糖代谢密切相关。CI 患者的肠道紊乱可能是通过葡萄糖代谢引起 CI 的原因之一，也可能被认为是一种潜在的疾病预测方法。
