Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.
Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan; Department of Neurology, KurashikiHeisei Hospital, 4-3-38, Oimatsu-cho, Kurashiki 710-0826, Japan.
J Clin Neurosci. 2020 Apr;74:76-80. doi: 10.1016/j.jocn.2020.01.085. Epub 2020 Jan 30.
There is a strong relationship between Alzheimer's disease (AD) and sleep problems, and a sleep condition is informative for evaluating the AD status. In the present study, we evaluated subjective sleep problems in AD and mild cognitive impairment (MCI) with self-check questionnaires and objective sleep problems with a convenient home-based portable device, WatchPAT. A total of 63 subjects with normal cognition (NC) (n = 22), MCI (n = 20), and AD (n = 21) were cross-sectionally investigated. AD patients showed a better self-check Pittsburgh sleep quality index (PSQI) score (*p < 0.05) than NC and MCI patients. On the other hand, WatchPAT analysis showed a significantly reduced rapid eye movement (REM) sleep (*p < 0.05) and increased light sleep in AD patients (*p < 0.05) compared with NC subjects, and mildly reduced REM and increased light sleep in MCI subjects. The present study revealed a gap between the subjective self-check sleep questions and the objective WatchPAT analysis in AD patients. Thus, a home-based sleep study with WatchPAT is a useful tool to detect an objective sleep problem in AD and the risk of MCI conversion into AD.
阿尔茨海默病 (AD) 与睡眠问题之间存在很强的关系，而睡眠状况对评估 AD 状态具有重要意义。在本研究中，我们使用自我评估问卷评估了 AD 和轻度认知障碍 (MCI) 的主观睡眠问题，并使用方便的家庭式便携式设备 WatchPAT 评估了客观睡眠问题。共对 63 名认知正常 (NC) (n=22)、MCI (n=20) 和 AD (n=21) 患者进行了横断面研究。AD 患者的匹兹堡睡眠质量指数 (PSQI) 自评得分更好 (*p<0.05)，优于 NC 和 MCI 患者。另一方面，与 NC 受试者相比，WatchPAT 分析显示 AD 患者的快速眼动 (REM) 睡眠显著减少 (*p<0.05)，浅睡眠增加 (*p<0.05)，而 MCI 患者的 REM 和浅睡眠略有减少。本研究揭示了 AD 患者主观自我评估睡眠问题和客观 WatchPAT 分析之间的差距。因此，使用 WatchPAT 进行家庭睡眠研究是一种有用的工具，可以检测 AD 中的客观睡眠问题以及 MCI 向 AD 转化的风险。
