Becker Maike, Levings Megan K, Daniel Carolin
Institute for Diabetes Research, Research Group Immune Tolerance in Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum München, Munich, Germany.
Deutsches Zentrum für Diabetesforschung (DZD), Munich, Germany.
Eur J Immunol. 2017 Nov;47(11):1867-1874. doi: 10.1002/eji.201646739. Epub 2017 Sep 20.
Obesity and type-2 diabetes (T2D) are associated with metabolic defects and inflammatory processes in fat depots. FoxP3 regulatory T cells (Tregs) control immune tolerance, and have an important role in controlling tissue-specific inflammation. In this mini-review we will discuss current insights into how cross-talk between T cells and adipose tissue shapes the inflammatory environment in obesity-associated metabolic diseases, focusing on the role of CD4 T cells and Tregs. We will also highlight potential opportunities for how the immunoregulatory properties of Tregs could be harnessed to control inflammation in obesity and T2D and emphasize the critical need for more research on humans to establish mechanisms that are conserved in both mice and humans.
肥胖和2型糖尿病（T2D）与脂肪组织中的代谢缺陷和炎症过程相关。叉头框蛋白P3调节性T细胞（Tregs）控制免疫耐受，并在控制组织特异性炎症中发挥重要作用。在本综述中，我们将讨论目前对于T细胞与脂肪组织之间的相互作用如何塑造肥胖相关代谢疾病中的炎症环境的见解，重点关注CD4 T细胞和Tregs的作用。我们还将强调利用Tregs的免疫调节特性来控制肥胖和T2D炎症的潜在机会，并强调迫切需要对人类进行更多研究，以确定在小鼠和人类中均保守的机制。
