[派尼胺增加老年人松果体褪黑素的合成]

[Pineamin increased pineal melatonin synthesis in elderly people].

作者信息

Trofimova S V, Linkova N S, Klimenko A A, Kvetnaia T V, Khavinson V Kh

机构信息

Saint-Petersburg Institute of Bioregulation and Gerontology, 3, Dynamo pr., St. Petersburg, 197110, Russian Federation;

Peter the Great Saint-Petersburg Polytechnic University, 29, Polytechnicheskaya str., St. Petersburg, 195251, Russian Federation.

出版信息

Adv Gerontol. 2017;30(3):422-426.

PMID:28849889

Abstract

It was investigated the influence of polypeptide complex Pineamin on the 6-sulfatoxymelatonin (aMT6S) excretion in urine by ELISA test of 55 elderly patients with diminished melatoninsynthesis pineal gland function. Pineamin in course dose 100 mg has increased night level of aMT6S urine excretion in 1,9 times in comparison with relevant value untreated. Similar effect was obtained early for medical drug Epithalamin. Epithalamin also restored melatonin level in human and animals during aging. Thus, Pineamin and Epithalamin have similar stimulate effect on melatonin synthesis in elderly people pineal gland.

摘要

通过酶联免疫吸附测定法（ELISA），对55名褪黑素合成功能减退的老年松果体功能患者进行研究，以探讨多肽复合物Pineamin对尿中6-硫酸氧褪黑素（aMT6S）排泄的影响。与未治疗的相关值相比，100mg疗程剂量的Pineamin使aMT6S尿排泄的夜间水平提高了1.9倍。早期使用药物Epithalamin也获得了类似的效果。Epithalamin还能在衰老过程中恢复人和动物体内的褪黑素水平。因此，Pineamin和Epithalamin对老年人松果体中的褪黑素合成具有相似的刺激作用。