Bondarenko L A, Anisimov V N
Biull Eksp Biol Med. 1992 Feb;113(2):194-5.
The biosynthesis of serotonin into melatonin was decreased in old (18-20-month) in comparison to young (4-5-month) male Wistar rats. 5-day morning injections to young and old rats with polypeptide pineal preparation (epithalamin) in a dose of 2.5 mg/kg of body weight induced the increase in the night peak of serotonin, N-acetylserotonin and melatonin in young and melatonin alone in old rats and did not influence 5-methoxytryptamine, 5-oxy- and 5-methoxyindoleacetic acids level. These data support suggestion of ultrashort loop between pineal peptides and indoles and that epithalamin increases the metabolism of serotonin into melatonin.
与年轻（4-5个月）雄性Wistar大鼠相比，老年（18-20个月）大鼠中血清素生物合成褪黑素的过程减少。以2.5mg/kg体重的剂量对年轻和老年大鼠进行为期5天的早晨多肽松果体制剂（epithalamin）注射，诱导年轻大鼠血清素、N-乙酰血清素和褪黑素的夜间峰值增加，而老年大鼠仅诱导褪黑素增加，且不影响5-甲氧基色胺、5-羟基和5-甲氧基吲哚乙酸水平。这些数据支持了松果体肽和吲哚之间存在超短回路的观点，以及epithalamin增加血清素向褪黑素代谢的观点。
