Department of Chemical Engineering, University of Washington , Seattle, Washington 98195, United States.
Langmuir. 2017 Oct 24;33(42):11264-11269. doi: 10.1021/acs.langmuir.7b02434. Epub 2017 Sep 8.
The development of nonfouling zwitterionic materials has a wide range of biomedical and engineering applications. This work delineates the design and synthesis of a new zwitterionic material based on a naturally occurring compatible solute, ectoine, which is known to possess additional protective properties that stabilize even whole cells against ultraviolet radiation or cytotoxins. These properties and applications of ectoine inspire us to design a functional monomer containing the natural zwitterion moiety of ectoine imparting nonfouling properties and the methacrylate moiety for polymerization. The synthesis route designed for the ectoine methacrylate monomer is simple with a high yield, which is characterized by nuclear magnetic resonance spectroscopy and mass spectrometry. After monomer synthesis, we have prepared a poly(ectoine) hydrogel via thermal polymerization. The equilibrium water content, degree of cross-linking, mechanical strength, and nonfouling properties are determined for polyectoine hydrogels with different cross-linking conditions. Poly(ectoine) hydrogels are shown to have highly hydrated and excellent nonfouling properties and can be considered to be a promising biomaterial.
开发抗污的两性离子材料在生物医药和工程领域有广泛的应用。本工作设计并合成了一种新型两性离子材料，它基于一种天然存在的相容溶质——海藻糖。海藻糖具有额外的保护特性，能稳定甚至是整个细胞免受紫外线辐射或细胞毒素的影响。这些特性和海藻糖的应用启发我们设计了一种功能性单体，其中包含了天然两性离子海藻糖的结构片段，赋予了抗污特性，以及甲基丙烯酸盐片段，用于聚合。设计的海藻糖甲基丙烯酸盐单体的合成路线简单，产率高，通过核磁共振波谱和质谱进行了表征。单体合成后，我们通过热聚合制备了聚（海藻糖）水凝胶。通过不同的交联条件，测定了聚海藻糖水凝胶的平衡水含量、交联度、机械强度和抗污性能。结果表明，聚（海藻糖）水凝胶具有高度水合和优异的抗污性能，可以被认为是一种有前途的生物材料。
