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急性疼痛服务的面貌变迁。

The changing face of acute pain services.

作者信息

Miclescu Adriana, Butler Stephen, Karlsten Rolf

机构信息

Multidisciplinary Pain Center, Uppsala University Hospital, Sweden.

Multidisciplinary Pain Center, Uppsala University Hospital, Sweden.

出版信息

Scand J Pain. 2017 Jul;16:204-210. doi: 10.1016/j.sjpain.2017.04.072. Epub 2017 May 25.

Abstract

BACKGROUND AND AIMS

Acute Pain Services have been implemented initially to treat inadequate postoperative pain. This study was undertaken to prospectively review the current challenges of the APS team in an academic hospital assessing the effects of its activity on both surgical and medical pain intensity. It also define the characteristics of the patients and the risk factors influencing the multiple visits from the APS team.

METHOD

This prospective cohort study was conducted at Uppsala University Hospital (a Swedish tertiary and quaternary care hospital) during one year. All the patients referred to the APS team were enrolled. A standardized data collection template of demographic data, medical history, pain diagnosis, associated diseases, duration of treatment, number of visits by the APS team and type of treatment was employed. The primary outcomes were pain scores before, after treatment and the number of follow-ups. The patients were visited by APS at regular intervals and divided by the number of visits by APS team into several groups: group 1 (one visit and up to 2 follow ups); group 2 (3 to 4 follow-ups); group 3 (5 to 9 follow-ups); group 4 (10 to 19 follow-ups); group 5 (>20 followups). The difference between groups were analyzed with ordinal logistic regression analyses.

RESULTS

Patients (n=730) (mean age 56±4, female 58%, men 42%) were distributed by service to medical (41%) and surgical (58%). Of these, 48% of patients reported a pain score of moderate to severe pain and 27% reported severe pain on the first assessment. On the last examination before discharge, they reported 25-30% less pain (P=0.002). The median NRS (numerical rating scores) decreased significantly from 9.6 (95% confidence interval, 8.7-9.9) to 6.3 (6.1-7.4) for the severe pain (P<0.0001), from 3.8 (3.2-4.3) to 2.4 (1.8-2.9) for the moderate pain. The odds ratio for frequent follow-ups of the patients between 18 and 85 years (n=609) was 2.33 (95% CI: 1.35-4.02) if the patient had a history of chronic neuropathic pain, 1.80(1.25-2.60) in case the patient had a history of chronic nociceptive pain, 2.06(1.30-3.26) if he had mental diseases, and 3.35(2.21-5.08) if he had opioid dependency at the time of consultation from APS. Strong predictors of frequent visits included female gender (P=0.04).

CONCLUSIONS

Beside the benefits of APS in reducing pain intensity, this study demonstrates that the focus of APS has been shifted from the traditional treatment of acute surgical pain to the clinical challenges of treating hospitalized patients with a high comorbidity of psychiatric diseases, opioid dependency and chronic pain.

IMPLICATIONS

The concept of an APS will ultimately be redefined according to the new clinical variables. In the light of the increasing number of patients with complex pain states and chronic pain, opioid dependency and psychiatric comorbidities it is mandatory that the interdisciplinary APS team should include other specialties besides the "classical interdisciplinary APS team", as psychiatry, psychology, rehabilitation and physiotherapy with experience in treating chronic pain patients.

摘要

背景与目的

急性疼痛服务最初是为治疗术后疼痛不充分而实施的。本研究旨在前瞻性地评估学术医院中急性疼痛服务(APS)团队当前面临的挑战,评估其活动对手术和医疗疼痛强度的影响。同时,本研究还定义了患者的特征以及影响APS团队多次就诊的危险因素。

方法

本前瞻性队列研究在乌普萨拉大学医院(一家瑞典三级和四级护理医院)进行,为期一年。所有转诊至APS团队的患者均被纳入研究。采用标准化的数据收集模板,收集人口统计学数据、病史、疼痛诊断、相关疾病、治疗持续时间、APS团队就诊次数以及治疗类型等信息。主要结局指标为治疗前、后的疼痛评分以及随访次数。APS团队定期对患者进行随访,并根据APS团队的就诊次数将患者分为几组:第1组(就诊1次及最多2次随访);第2组(3至4次随访);第3组(5至9次随访);第4组(10至19次随访);第5组(>20次随访)。采用有序逻辑回归分析对组间差异进行分析。

结果

患者(n = 730)(平均年龄56±4岁,女性占58%,男性占42%)按服务科室分为内科(41%)和外科(58%)。其中,48%的患者在首次评估时报告中度至重度疼痛,27%报告重度疼痛。在出院前的最后一次检查中,他们报告疼痛减轻了25 - 30%(P = 0.002)。重度疼痛患者的数字评分量表(NRS)中位数从9.6(95%置信区间,8.7 - 9.9)显著降至6.3(6.1 - 7.4)(P < 0.0001),中度疼痛患者从3.8(3.2 - 4.3)降至2.4(1.8 - 2.9)。18至85岁患者(n = 609)中,若患者有慢性神经病理性疼痛病史,频繁随访的优势比为2.33(95%CI:1.35 - 4.02);若有慢性伤害性疼痛病史,优势比为1.80(1.25 - 2.60);若有精神疾病,优势比为2.06(1.30 - 3.26);若在APS团队会诊时存在阿片类药物依赖,优势比为3.35(2.21 - 5.08)。频繁就诊的强预测因素包括女性性别(P = 0.04)。

结论

除了APS在减轻疼痛强度方面的益处外,本研究表明,APS的重点已从传统的急性手术疼痛治疗转向治疗合并精神疾病、阿片类药物依赖和慢性疼痛的住院患者所面临的临床挑战。

启示

APS的概念最终将根据新的临床变量重新定义。鉴于患有复杂疼痛状态、慢性疼痛、阿片类药物依赖和精神疾病共病的患者数量不断增加,跨学科的APS团队除了“经典的跨学科APS团队”外,还应包括其他专业,如具有治疗慢性疼痛患者经验的精神病学、心理学、康复和物理治疗专业。

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