School of Engineering, Rankine Building, University of Glasgow, Glasgow G12 8LT, UK.
School of Engineering, Rankine Building, University of Glasgow, Glasgow G12 8LT, UK.
Biosens Bioelectron. 2018 Feb 15;100:23-27. doi: 10.1016/j.bios.2017.08.038. Epub 2017 Aug 31.
We report on the design and fabrication of a hybrid sensor that integrates transmission-mode localized surface plasmonic resonance (LSPR) into a quartz crystal microbalance (QCM) for studying biochemical surface reactions. The coupling of LSPR nanostructures and a QCM allows optical spectra and QCM resonant frequency shifts to be recorded simultaneously and analyzed in real time for a given surface adsorption process. This integration simplifies the conventional combination of SPR and QCM and has the potential to be miniaturized for application in point-of-care (POC) diagnostics. The influence of antibody-antigen recognition effect on both the QCM and LSPR has been analyzed and discussed.
我们报告了一种混合传感器的设计和制造，该传感器将传输模式局域表面等离子体共振（LSPR）集成到石英晶体微天平（QCM）中，用于研究生化表面反应。LSPR 纳米结构与 QCM 的耦合允许同时记录光学光谱和 QCM 共振频率的偏移，并实时分析给定的表面吸附过程。这种集成简化了 SPR 和 QCM 的传统组合，并且有可能小型化用于即时护理（POC）诊断。分析和讨论了抗体-抗原识别效应对 QCM 和 LSPR 的影响。
