Ongeri L, McCulloch C E, Neylan T C, Bukusi E, Macfarlane S B, Othieno C, Ngugi A K, Meffert S M
Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya; Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya.
Department of Epidemiology and Biostatistics, University of California, San Francisco, USA; Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya.
J Affect Disord. 2018 Jan 1;225:413-421. doi: 10.1016/j.jad.2017.08.059. Epub 2017 Aug 31.
Low-and-Middle-Income-Countries (LMICs) account for 75% of global suicides. While primary care populations in high-income countries (HIC) typically have higher prevalence of suicidal behavior relative to general populations, few studies have explored suicidal behavior among general medical outpatients in LMICs. This study addresses the research gap by characterizing potential risk factors for suicidal ideation in a large general medical outpatient setting in rural Kenya.
A cross-sectional study of adult general medical outpatients attending a rural sub-county hospital in Kaloleni, Kenya. Primary outcomes included major depressive disorder (MDD), posttraumatic stress disorder (PTSD) and suicidal behavior measured by the Mini International Neuropsychiatric Interview (MINI 5.0). We use binary logistic regression to model suicidality, mental disorders, intimate partner violence, and lifetime abuse.
394 outpatients completed the assessment. The prevalence of SI over the past month was 20%. 18% of those with suicidal ideation over the past month also attempted suicide in the past month. Participants who met criteria for MDD (suicidality item removed) were 19 times [CI: 4.56, 79.05] more likely to report suicidal ideation compared to those without MDD (adjusted odds ratio 12.15 [CI: 2.66, 55.49]).
This was a cross sectional study design with convenience sampling and hence vulnerable to selection and recall bias.
The prevalence of SI and its strong association with actual suicide attempt in this population, make an urgent public health case for intervention. These data identify MDD as a highly significant correlate of SI.
中低收入国家(LMICs)的自杀人数占全球自杀人数的75%。虽然高收入国家(HIC)的初级保健人群中自杀行为的患病率通常高于普通人群,但很少有研究探讨中低收入国家普通内科门诊患者的自杀行为。本研究通过描述肯尼亚农村一个大型普通内科门诊环境中自杀意念的潜在风险因素,填补了这一研究空白。
对肯尼亚卡洛莱尼一个农村次县级医院的成年普通内科门诊患者进行横断面研究。主要结局包括重度抑郁症(MDD)、创伤后应激障碍(PTSD)以及通过迷你国际神经精神访谈(MINI 5.0)测量的自杀行为。我们使用二元逻辑回归对自杀倾向、精神障碍、亲密伴侣暴力和终身虐待进行建模。
394名门诊患者完成了评估。过去一个月自杀意念的患病率为20%。在过去一个月有自杀意念的患者中,18%在过去一个月也尝试过自杀。符合MDD标准(去除自杀倾向项目)的参与者报告自杀意念的可能性是没有MDD的参与者的19倍[CI:4.56,79.05](调整后的优势比为12.15[CI:2.66,55.49])。
这是一项采用便利抽样的横断面研究设计,因此容易受到选择偏倚和回忆偏倚的影响。
该人群中自杀意念的患病率及其与实际自杀未遂的强烈关联,为干预提供了紧迫的公共卫生依据。这些数据表明MDD是自杀意念的一个高度显著的相关因素。