营养摄入对早产儿锌水平的影响：一项观察性研究。
Nutritional Intake Influences Zinc Levels in Preterm Newborns: An Observational Study.
机构信息
Department of Maternal and Child Health, University of Roma La Sapienza, 00161 Rome, Italy.
Service de Néonatologie. Centre Hospitalier Universitaire Sud Réunion, BP 350, 97448 Saint-Pierre Cedex, La Réunion, France.
出版信息
Nutrients. 2020 Feb 19;12(2):529. doi: 10.3390/nu12020529.
(1) Background: Zinc is a key element for protein synthesis in preterm newborns. Early aggressive nutrition, promoting protein synthesis, may increase zinc consumption; (2) Methods: We performed a prospective observational study, to assess the relationship between early macronutrients intake and serum zinc levels, in preterm newborns with Gestational Age (GA) of 24-35 weeks, consecutively observed in Neonatal Intensive Care Unit (NICU). (3) Results: We enrolled 130 newborns (GA 31.5 ± 2.8). A significant negative correlation between serum zinc level at 28 days of life and energy (r -0.587, < 0.001) and protein intake (r -0.556, < 0.001) in the first week of life was observed. Linear regression analysis showed that zinc levels depended on energy (β -0.650; < 0.001) and protein (β -0.669; < 0.001) intake given through parenteral nutrition (PN) in the first week of life; (4) Conclusions: zinc status of preterm neonates was influenced by early protein and energy intake. An additional zinc supplementation should be considered when high protein and energy intake are received by preterm newborns in the first week of life.
(1) 背景：锌是早产儿蛋白质合成的关键元素。早期积极的营养支持，促进蛋白质合成，可能会增加锌的消耗；(2) 方法：我们进行了一项前瞻性观察研究，以评估 24-35 周胎龄的早产儿在新生儿重症监护病房（NICU）连续观察期间，早期宏量营养素摄入与血清锌水平之间的关系。(3) 结果：我们共纳入 130 名新生儿（胎龄 31.5 ± 2.8 周）。在生命的第 28 天，血清锌水平与生命的第一周的能量（r=-0.587， < 0.001）和蛋白质摄入（r=-0.556， < 0.001）呈显著负相关。线性回归分析显示，锌水平取决于生命第一周通过肠外营养（PN）给予的能量（β=-0.650； < 0.001）和蛋白质（β=-0.669； < 0.001）摄入；(4) 结论：早产儿的锌状态受早期蛋白质和能量摄入的影响。对于在生命的第一周接受高蛋白和高能量摄入的早产儿，应考虑额外补充锌。
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