Department of Urology, Qilu Hospital of Shandong University, No.107, West Wen Hua Road, Jinan City, 250012, Shandong Province, People's Republic of China.
Department of Urology, Qingdao Municipal Hospital, Qingdao University, No.5, Middle Dong Hai Road, Qingdao City, 266071, Shandong Province, People's Republic of China.
World J Surg Oncol. 2017 Aug 29;15(1):165. doi: 10.1186/s12957-017-1238-9.
Prostate cancer is known to have ethnic and regional differences. The study aimed to clinically evaluate the detection rate of prostate cancer on transrectal ultrasonography (TRUS)-guided prostate biopsy and analyze its characteristics among the northern Han Chinese population at a single center.
Between October 2009 and September 2016, a total of 1027 Chinese men, who had undergone TRUS-guided prostate biopsy at Qingdao Municipal Hospital, were retrospectively analyzed. Prostate biopsies were performed in the case of an abnormally elevated serum PSA level, and/or abnormal digital rectal examination (DRE) findings, and/or suspicious prostatic imaging findings.
Of the 1022 men enrolled in the analysis, 438 patients (42.8%) were diagnosed with prostate adenocarcinoma histologically. When serum PSA levels were divided into five subgroups (less than 4.0, 4.0 to 10.0, 10.0 to 20.0, 20.0 to 100.0, and ≥ 100.0 ng/ml), the detection rates of prostate cancer were 12.4, 15.9, 34.1, 66.2, and 93.8%, respectively. With serum PSA levels of 4.0 to 10.0 ng/ml, the cancer detection rates for a normal DRE and a suspect DRE finding were 13.5 and 58.2%, respectively. Accordingly, the cancer detection rates for a normal imaging and a suspect imaging finding were 13.5 and 58.2%, respectively. Besides, a large proportion of the patients were in the clinically advanced stage.
The present study data reported a relatively higher prostate cancer detection rate of 42.8% and that the majority of the patients presented with clinically advanced prostate cancers within a local clinical urologic practice. An early detection and screening program for prostate cancer is of great need to reduce the burden from this disease among the northern Han Chinese population.
前列腺癌存在种族和地区差异。本研究旨在对经直肠超声（TRUS）引导下前列腺穿刺活检的前列腺癌检出率进行临床评估，并分析该地区汉族人群的特点。
回顾性分析 2009 年 10 月至 2016 年 9 月在青岛市市立医院行 TRUS 引导下前列腺穿刺活检的 1027 例中国男性患者的临床资料。对于血清前列腺特异抗原（PSA）水平异常升高、直肠指诊（DRE）异常、前列腺影像学检查异常的患者，行前列腺穿刺活检。
1022 例患者纳入分析，其中 438 例（42.8%）患者前列腺穿刺活检组织病理诊断为前列腺腺癌。当血清 PSA 水平分为五组（<4.0、4.0～10.0、10.0～20.0、20.0～100.0、≥100.0 ng/ml）时，前列腺癌的检出率分别为 12.4%、15.9%、34.1%、66.2%和 93.8%。血清 PSA 水平在 4.0～10.0 ng/ml 时，DRE 正常和可疑患者的前列腺癌检出率分别为 13.5%和 58.2%，相应的影像学正常和可疑患者的前列腺癌检出率分别为 13.5%和 58.2%。此外，大部分患者处于临床晚期。
本研究数据显示，该地区汉族人群前列腺癌的检出率相对较高，为 42.8%，且大多数患者的前列腺癌处于临床晚期。因此，需要开展前列腺癌早期检测和筛查项目，以降低该地区汉族人群前列腺癌的发病负担。
