外泌体 miRNA 与癌症相关成纤维细胞中的 miRNA 失调。
Exosomal miRNAs and miRNA dysregulation in cancer-associated fibroblasts.
机构信息
Department of Oncology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China.
Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, People's Republic of China.
出版信息
Mol Cancer. 2017 Aug 29;16(1):148. doi: 10.1186/s12943-017-0718-4.
PURPOSE
The present review aimed to assess the role of exosomal miRNAs in cancer-associated fibroblasts (CAFs), normal fibroblasts (NFs), and cancer cells. The roles of exosomal miRNAs and miRNA dysregulation in CAF formation and activation were summarized.
METHODS
All relevant publications were retrieved from the PubMed database, with key words such as CAFs, CAF, stromal fibroblasts, cancer-associated fibroblasts, miRNA, exosomal, exosome, and similar terms.
RESULTS
Recent studies have revealed that CAFs, NFs, and cancer cells can secrete exosomal miRNAs to affect each other. Dysregulation of miRNAs and exosomal miRNAs influence the formation and activation of CAFs. Furthermore, miRNA dysregulation in CAFs is considered to be associated with a secretory phenotype change, tumor invasion, tumor migration and metastasis, drug resistance, and poor prognosis.
CONCLUSIONS
Finding of exosomal miRNA secretion provides novel insights into communication among CAFs, NFs, and cancer cells. MicroRNA dysregulation is also involved in the whole processes of CAF formation and function. Dysregulation of miRNAs in CAFs can affect the secretory phenotype of the latter cells.
目的
本综述旨在评估外泌体 miRNA 在癌相关成纤维细胞（CAFs）、正常成纤维细胞（NFs）和癌细胞中的作用。总结了外泌体 miRNA 及其失调在 CAF 形成和激活中的作用。
方法
从 PubMed 数据库中检索所有相关文献，关键词包括 CAFs、CAF、基质成纤维细胞、癌相关成纤维细胞、miRNA、外泌体、外泌体和类似术语。
结果
最近的研究表明，CAFs、NFs 和癌细胞可以分泌外泌体 miRNA 来相互影响。miRNA 失调和外泌体 miRNA 影响 CAFs 的形成和激活。此外，CAFs 中的 miRNA 失调被认为与分泌表型改变、肿瘤侵袭、肿瘤迁移和转移、耐药性和预后不良有关。
结论
外泌体 miRNA 分泌的发现为 CAFs、NFs 和癌细胞之间的通讯提供了新的见解。miRNA 失调也参与了 CAF 形成和功能的全过程。CAFs 中 miRNAs 的失调会影响后者细胞的分泌表型。
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