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[自发性高血压大鼠脑内氧分压的分布]

[Distribution of oxygen tension in the brain of spontaneously hypertensive rats].

作者信息

Aleksandrova T B, Kilibaeva G S, Riasina T V, Demchenko I T, Moskalenko Iu E

出版信息

Biull Eksp Biol Med. 1987 Jan;103(1):15-7. doi: 10.1007/BF00840123.

DOI:10.1007/BF00840123
PMID:3801641
Abstract

The distribution of cerebral tissue pO2 in spontaneously hypertensive Okamoto-Aoki rats (SHR) and normotensive Wistar-Kyoto rats (WK) was studied by means of polarographic microelectrodes 1-3 microns in diameter. SHR exhibited pO2 shifts towards low values and an increased heterogeneity of pO2 distribution in the cerebral tissue. Morphological studies of the brain have revealed diffuse and focal ischemia in the grey and white matter of the brain in SHR.

摘要

采用直径为1 - 3微米的极谱微电极研究了自发性高血压冈本 - 青木大鼠(SHR)和正常血压的Wistar - Kyoto大鼠(WK)脑组织中氧分压(pO2)的分布。SHR表现出脑组织中pO2向低值偏移且pO2分布的异质性增加。对大脑的形态学研究显示,SHR大脑的灰质和白质存在弥漫性和局灶性缺血。

相似文献

1
[Distribution of oxygen tension in the brain of spontaneously hypertensive rats].[自发性高血压大鼠脑内氧分压的分布]
Biull Eksp Biol Med. 1987 Jan;103(1):15-7. doi: 10.1007/BF00840123.
2
Opioid peptides in pituitary gland, brain regions and peripheral tissues of spontaneously hypertensive and Wistar-Kyoto normotensive rats.自发性高血压大鼠和Wistar-Kyoto正常血压大鼠垂体、脑区及外周组织中的阿片肽
Brain Res. 1988 Feb 9;440(2):333-40. doi: 10.1016/0006-8993(88)91003-7.
3
Tissue distribution of acebutolol in mature normotensive and stroke-prone spontaneously hypertensive rats.醋丁洛尔在成熟正常血压和易中风自发性高血压大鼠中的组织分布。
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1987;87(1):83-6. doi: 10.1016/0742-8413(87)90186-1.
4
Cerebral microregional oxygen balance during chronic versus acute hypertension in middle cerebral artery occluded rats.大脑中动脉闭塞大鼠慢性与急性高血压期间的脑微区氧平衡
Anesth Analg. 1996 Mar;82(3):587-92. doi: 10.1097/00000539-199603000-00028.
5
Kappa opioid receptor activity in spontaneously hypertensive rats.自发性高血压大鼠中κ阿片受体的活性
J Pharmacol Exp Ther. 1988 May;245(2):460-5.
6
Increased oxidative metabolism in renal tubules from spontaneously hypertensive rats.自发性高血压大鼠肾小管中氧化代谢增加。
Am J Physiol. 1989 Nov;257(5 Pt 2):F818-25. doi: 10.1152/ajprenal.1989.257.5.F818.
7
[Protein kinase C activity in the brain tissue of spontaneously hypertensive rats].[自发性高血压大鼠脑组织中的蛋白激酶C活性]
Biull Eksp Biol Med. 1989 Jul;108(7):42-4.
8
Mechanics and composition of cerebral arterioles in renal and spontaneously hypertensive rats.肾性高血压大鼠和自发性高血压大鼠脑小动脉的力学特性与组成
Hypertension. 1993 Jun;21(6 Pt 1):816-26. doi: 10.1161/01.hyp.21.6.816.
9
Levels of immunoreactive angiotensin II in microdissected nuclei from adult WKY and SH rat brain.成年WKY和SH大鼠脑显微切割细胞核中免疫反应性血管紧张素II的水平。
Clin Exp Hypertens A. 1989;11(1):103-17. doi: 10.3109/10641968909035294.
10
Free amino acid pools in the spontaneously hypertensive rat: a longitudinal study.自发性高血压大鼠的游离氨基酸池:一项纵向研究。
J Nutr. 1988 May;118(5):579-87. doi: 10.1093/jn/118.5.579.

本文引用的文献

1
Development of microvascular rarefaction in the spontaneously hypertensive rat.自发性高血压大鼠微血管稀疏的发展
Am J Physiol. 1982 Aug;243(2):H243-51. doi: 10.1152/ajpheart.1982.243.2.H243.
2
[Changes in the morphometric indices of the microvascular bed of the brain in experimental hypertension].[实验性高血压时脑微血管床形态学指标的变化]
Biull Eksp Biol Med. 1984 Sep;98(9):366-8.
3
[A study of the intercapillary distribution of PO2 in the brain using microelectrodes].[一项使用微电极对大脑中氧分压的毛细血管间分布的研究]
Fiziol Zh SSSR Im I M Sechenova. 1975 Sep;61(9):1310-7.
4
Oxygen consumption in the spontaneously hypertensive rat.自发性高血压大鼠的耗氧量
Proc Soc Exp Biol Med. 1978 Dec;159(3):449-52. doi: 10.3181/00379727-159-40368.
5
Sympathetic nerve activity and blood pressure in normotensive backcross rats genetically related to the spontaneously hypertensive rat.与自发性高血压大鼠有遗传关系的正常血压回交大鼠的交感神经活动和血压
Hypertension. 1979 Nov-Dec;1(6):598-604. doi: 10.1161/01.hyp.1.6.598.
6
Arteriolar closure mediated by hyperresponsiveness to norepinephrine in hypertensive rats.高血压大鼠中由去甲肾上腺素高反应性介导的小动脉关闭
Am J Physiol. 1979 Jan;236(1):H157-64. doi: 10.1152/ajpheart.1979.236.1.H157.