Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar 125 001, India.
Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar 125 001, India.
Int J Biol Macromol. 2018 Jan;106:1184-1191. doi: 10.1016/j.ijbiomac.2017.08.128. Epub 2017 Aug 26.
In the present study polyelectrolyte complex between carboxymethyl gum katira and chitosan were prepared and evaluated for drug delivery using ofloxacin as model drug. The carboxymethyl gum katira-chitosan polyelectrolyte complex was characterized by FTIR, DSC, TGA, DTG, XRD and SEM. The influence of concentration of CMGK/CH and drug loading (%) on yield (%) and drug entrapment (%) was studied using response surface methodology. The result of the study revealed that increasing the relative proportion of CMGK/CH in carboxymethyl gum katira-chitosan polyelectrolyte complex decreases the % yield and increases the % drug entrapment. The optimal calculated parameters were polymer ratio (CMGK/CH) 2.13 and drug loading 50 (%w/w). The optimized batch of carboxymethyl gum katira-chitosan polyelectrolyte complex had yield of 69.04%, entrapment efficiency of ofloxacin 84.86%. Further, the optimized batch of carboxymethyl gum katira-chitosan polyelectrolyte complex releases ofloxacin 84.32% following Higuchi's square-root kinetics.
在本研究中，制备了羧甲基瓜尔胶 katira 与壳聚糖的聚电解质复合物，并以氧氟沙星为模型药物评价其药物传递性能。采用傅里叶变换红外光谱（FTIR）、差示扫描量热法（DSC）、热重分析（TGA）、导数热重分析（DTG）、X 射线衍射（XRD）和扫描电子显微镜（SEM）对羧甲基瓜尔胶 katira-壳聚糖聚电解质复合物进行了表征。采用响应面法研究了 CMGK/CH 浓度和载药量（%）对产率（%）和药物包封率（%）的影响。研究结果表明，增加羧甲基瓜尔胶 katira-壳聚糖聚电解质复合物中 CMGK/CH 的相对比例会降低产率，而增加药物包封率。最佳计算参数为聚合物比（CMGK/CH）2.13 和载药量 50（%w/w）。优化批次的羧甲基瓜尔胶 katira-壳聚糖聚电解质复合物的产率为 69.04%，氧氟沙星包封效率为 84.86%。此外，优化批次的羧甲基瓜尔胶 katira-壳聚糖聚电解质复合物遵循 Higuchi 平方根动力学释放 84.32%的氧氟沙星。
