抱紧我，但别太紧——血管生成中的内皮细胞-细胞连接。
Hold Me, but Not Too Tight-Endothelial Cell-Cell Junctions in Angiogenesis.
机构信息
Integrative Vascular Biology Laboratory, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125, Berlin, Germany.
DZHK (German Centre for Cardiovascular Research), partner site Berlin.
出版信息
Cold Spring Harb Perspect Biol. 2018 Aug 1;10(8):a029223. doi: 10.1101/cshperspect.a029223.
Abstract
Endothelial cell-cell junctions must perform seemingly incompatible tasks during vascular development-providing stable connections that prevent leakage, while allowing dynamic cellular rearrangements during sprouting, anastomosis, lumen formation, and functional remodeling of the vascular network. This review aims to highlight recent insights into the molecular mechanisms governing endothelial cell-cell adhesion in the context of vascular development.
摘要
内皮细胞-细胞连接在血管发育过程中必须执行看似相互矛盾的任务——提供稳定的连接以防止渗漏，同时允许在发芽、吻合、管腔形成和血管网络的功能重塑过程中发生动态细胞重排。本文旨在强调在血管发育背景下，关于内皮细胞-细胞黏附的分子机制的最新研究进展。
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