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Designed metalloenediyne warheads damage DNA and outpace DNA polymerase.

作者信息

Kirk Martin L

机构信息

Department of Chemistry and Chemical Biology, The University of New Mexico, Albuquerque, NM 87131

出版信息

Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):9497-9499. doi: 10.1073/pnas.1712545114. Epub 2017 Aug 29.

Abstract
摘要

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本文引用的文献

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Metal-mediated diradical tuning for DNA replication arrest via template strand scission.
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Copper is required for oncogenic BRAF signalling and tumorigenesis.
Nature. 2014 May 22;509(7501):492-6. doi: 10.1038/nature13180. Epub 2014 Apr 9.
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Utilizing redox-mediated Bergman cyclization toward the development of dual-action metalloenediyne therapeutics.
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Regulation of DNA repair throughout the cell cycle.
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Metal complex-DNA interactions: from transcription inhibition to photoactivated cleavage.
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