Satoh M S, Lindahl T
Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Hertfordshire, United Kingdom.
Cancer Res. 1994 Apr 1;54(7 Suppl):1899s-1901s.
Oxidative DNA damage, including both mutagenic and cytotoxic lesions, is implicated in aging and cancer. Studies of the processes which correct such damage in mammalian cells are, however, still in their early stages. Here we have summarized our recent work which demonstrates new features of mammalian oxidative DNA damage repair, such as (a) a functional role for poly(ADP-ribosyl)ation in the rejoining of DNA strand breaks and (b) the defective repair of oxidative DNA damage in xeroderma pigmentosum cells.
包括诱变和细胞毒性损伤在内的氧化性DNA损伤与衰老和癌症有关。然而，对哺乳动物细胞中纠正此类损伤过程的研究仍处于早期阶段。在此，我们总结了我们最近的工作，这些工作揭示了哺乳动物氧化性DNA损伤修复的新特征，例如：（a）聚（ADP-核糖基）化在DNA链断裂重新连接中的功能作用；（b）着色性干皮病细胞中氧化性DNA损伤的修复缺陷。
