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突触后长时程增强作用发生于树突谷氨酸应用与突触激活的偶联之后。

Postsynaptic long-term potentiation follows coupling of dendritic glutamate application and synaptic activation.

作者信息

Hvalby O, Lacaille J C, Hu G Y, Andersen P

出版信息

Experientia. 1987 Jun 15;43(6):599-601. doi: 10.1007/BF02126343.

DOI:10.1007/BF02126343
PMID:2885212
Abstract

Dendritic depolarization, which seems to be involved in the induction of long-term potentiation (LTP), was elicited by localized glutamate application. When paired to low frequency synaptic activation in the same area, the subsequent changes had features in common with LTP, expressed as an increased probability of firing and shorter spike latency. The EPSP was not significantly increased.

摘要

树突去极化似乎参与了长时程增强(LTP)的诱导,它是通过局部应用谷氨酸引发的。当与同一区域的低频突触激活配对时,随后的变化具有与LTP相同的特征,表现为放电概率增加和峰潜伏期缩短。兴奋性突触后电位(EPSP)没有显著增加。

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本文引用的文献

1
Possible mechanisms for long-lasting potentiation of synaptic transmission in hippocampal slices from guinea-pigs.豚鼠海马切片中突触传递长时程增强的可能机制。
J Physiol. 1980 May;302:463-82. doi: 10.1113/jphysiol.1980.sp013256.
2
Climbing fibre induced depression of both mossy fibre responsiveness and glutamate sensitivity of cerebellar Purkinje cells.攀缘纤维引起小脑浦肯野细胞的苔藓纤维反应性和谷氨酸敏感性降低。
J Physiol. 1982 Mar;324:113-34. doi: 10.1113/jphysiol.1982.sp014103.
3
Heterosynaptic modulation of homosynaptic long-lasting potentiation in the hippocampal slice.
在大鼠海马切片中诱导长时程增强的兴奋性突触后电位-峰电位(E-S)成分后,观察到放电阈值降低。
Exp Brain Res. 1990;79(3):633-41. doi: 10.1007/BF00229331.
4
Synaptically triggered action potentials begin as a depolarizing ramp in rat hippocampal neurones in vitro.在体外培养的大鼠海马神经元中,突触触发的动作电位始于去极化斜坡。
J Physiol. 1992;453:663-87. doi: 10.1113/jphysiol.1992.sp019250.
Acta Physiol Scand. 1983 Dec;119(4):455-8. doi: 10.1111/j.1748-1716.1983.tb07362.x.
4
Long-term potentiation of hippocampal synaptic transmission affects rate of behavioral learning.
Science. 1984 May 11;224(4649):627-30. doi: 10.1126/science.6324350.
5
Magnesium gates glutamate-activated channels in mouse central neurones.镁离子控制小鼠中枢神经元中谷氨酸激活的通道。
Nature. 1984;307(5950):462-5. doi: 10.1038/307462a0.
6
Changes in translation of synaptic excitation to dentate granule cell discharge accompanying long-term potentiation. I. Differences between normal and reinnervated dentate gyrus.伴随长时程增强的突触兴奋向齿状颗粒细胞放电的转化变化。I. 正常和重新支配的齿状回之间的差异。
J Neurophysiol. 1981 Aug;46(2):324-38. doi: 10.1152/jn.1981.46.2.324.
7
Increased resting and evoked release of transmitter following repetitive electrical tetanization in hippocampus: a biochemical correlate to long-lasting synaptic potentiation.
Brain Res. 1981 Mar 16;208(2):436-41. doi: 10.1016/0006-8993(81)90573-4.
8
N-methyl aspartate activates voltage-dependent calcium conductance in rat hippocampal pyramidal cells.N-甲基-D-天冬氨酸激活大鼠海马锥体细胞中的电压依赖性钙电导。
J Physiol. 1983 Oct;343:385-405. doi: 10.1113/jphysiol.1983.sp014899.
9
Long-term potentiation of the perforant path in vivo is associated with increased glutamate release.在体情况下,穿通通路的长期增强与谷氨酸释放增加有关。
Nature. 1982 Jun 10;297(5866):496-8. doi: 10.1038/297496a0.
10
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.在麻醉兔的齿状区,刺激穿通通路后突触传递的长时程增强。
J Physiol. 1973 Jul;232(2):331-56. doi: 10.1113/jphysiol.1973.sp010273.