Reddy Konda Sireesha, Chittoria Ravi Kumar, Babu Preethitha, Marimuthu Senthil Kumaran, Kumar Sudhanva Hemanth, Subbarayan Elan Kumar, Chavan Vinayak, Mohapatra Devi Prasad, Sivakumar Dinesh Kumar, Friji M T
Department of Plastic Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
J Cutan Aesthet Surg. 2017 Apr-Jun;10(2):72-75. doi: 10.4103/JCAS.JCAS_100_16.
Graft fixation is important for graft take. Fibrin glue has been proposed as an ideal material, because of its human origin and it provides firm adhesion in seconds or minutes.
To evaluate the efficiency of fibrin glue, in increasing the take of skin graft. Assessment includes surgical time taken for graft fixation, haematoma/seroma formation, engraftment and wound closure by day 14.
The study is an observational prospective study conducted in the Department of Plastic Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, from January 2016 to June 2016. Sixteen patients who underwent split skin grafting were assessed during the study period. Fibrin glue was used on the recipient bed before grafting.
Better haemostasis and graft adhesion, with a significant reduction of surgical time, were noted.
The safety profile of fibrin glue was excellent as indicated by the lack of any related serious adverse experiences. These findings demonstrate that it is safe and effective for attachment of skin grafts, with outcomes at least as good as conventional methods.
移植物固定对于移植物存活很重要。纤维蛋白胶因其来源于人体且能在数秒或数分钟内提供牢固黏附力，已被提议作为一种理想材料。
评估纤维蛋白胶在提高皮肤移植物存活率方面的效果。评估内容包括移植物固定所需的手术时间、血肿/血清肿形成情况、移植成功率以及术后14天伤口闭合情况。
本研究为一项观察性前瞻性研究，于2016年1月至2016年6月在本地治里市贾瓦哈拉尔尼赫鲁研究生医学教育与研究学院整形外科学系开展。研究期间对16例行中厚皮片移植的患者进行了评估。在移植前，将纤维蛋白胶应用于受区创面。
观察到止血效果更佳、移植物黏附良好，且手术时间显著缩短。
未出现任何相关严重不良事件，表明纤维蛋白胶的安全性极佳。这些研究结果表明，纤维蛋白胶用于皮肤移植物固定安全有效，其效果至少与传统方法相当。
