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分数二氧化碳、长脉冲钕:钇铝石榴石激光和脉冲染料激光在瘢痕疙瘩治疗中的应用

Fractional Carbon Dioxide, Long Pulse Nd:YAG and Pulsed Dye Laser in the Management of Keloids.

作者信息

Annabathula Ashwini, Sekar C Shanmuga, Srinivas C R

机构信息

Department of Dermatology, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India.

出版信息

J Cutan Aesthet Surg. 2017 Apr-Jun;10(2):76-80. doi: 10.4103/JCAS.JCAS_136_16.

Abstract

BACKGROUND

Keloids are abnormal wound responses characterised by excessive deposition of collagen and glycoprotein. They are both aesthetically and symptomatically distressing for most of the patients. There are reports of keloid management with pulsed dye laser (PDL), fractional carbon dioxide (CO) laser and neodymium-doped yttrium aluminium garnet (Nd:YAG) laser individually and also in combination of CO with PDL and CO with Nd:YAG. Here, we discuss a combination of all the 3 lasers as a therapy for keloids.

AIM

This study aims to assess the efficacy of fractional CO laser, long pulse Nd:YAG laser and PDL in the management of keloids.

MATERIALS AND METHODS

Fifteen patients with keloids were treated by fractional CO laser, followed by PDL and long pulse Nd:YAG laser at monthly intervals. Four patients discontinued the study and were lost for follow-up. Photographs were taken at the beginning of the treatment and at the end of five sessions. Clinical improvement was analysed based on a visual analogue scale graded by three blinded observers after assessing the clinical photographs for the improvement in size, colour and aesthetic impression.

RESULTS

Of the 11 patients, one patient had excellent improvement, one patient had good improvement, four patients had moderate improvement, two patients had mild improvement and three had no improvement.

CONCLUSION

Lasers may have a synergistic effect when combined with other modalities of treatment but cannot be used as monotherapy in the treatment of keloids.

摘要

背景

瘢痕疙瘩是异常的伤口反应,其特征是胶原蛋白和糖蛋白过度沉积。对大多数患者来说,它们在美观和症状方面都令人苦恼。有关于单独使用脉冲染料激光(PDL)、二氧化碳(CO)分次激光和掺钕钇铝石榴石(Nd:YAG)激光治疗瘢痕疙瘩的报道,也有关于CO与PDL联合以及CO与Nd:YAG联合治疗瘢痕疙瘩的报道。在此,我们讨论将这三种激光联合起来作为瘢痕疙瘩的一种治疗方法。

目的

本研究旨在评估二氧化碳分次激光、长脉冲Nd:YAG激光和PDL治疗瘢痕疙瘩的疗效。

材料与方法

15例瘢痕疙瘩患者接受二氧化碳分次激光治疗,随后每月间隔依次接受PDL和长脉冲Nd:YAG激光治疗。4例患者中断研究并失访。在治疗开始时和五个疗程结束时拍照。在由三名不知情的观察者根据视觉模拟量表对临床照片进行评估,以确定大小、颜色和美观印象的改善情况后,分析临床改善情况。

结果

11例患者中,1例患者改善极佳,1例患者改善良好,4例患者改善中等,2例患者改善轻微,3例患者无改善。

结论

激光与其他治疗方式联合时可能具有协同作用,但不能作为瘢痕疙瘩治疗的单一疗法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d90/5561714/305992810c67/JCAS-10-76-g006.jpg

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