Shin Hui Young, Park Yu Jeong, Choi Woo Kyoung, Sim Hyun Bo, Lee Seung Ho, Lee Ai Young, Hong Jong Soo
Department of Dermatology, Dongguk University Ilsan Hospital, College of Medicine, Dongguk University, Goyang, Korea.
Ann Dermatol. 2024 Dec;36(6):348-354. doi: 10.5021/ad.23.160.
Various treatment modalities are used to treat keloids. However, a comprehensive assessment comparing the effectiveness of these modalities in terms of patient-reported outcomes is warranted.
To assess and compare the effectiveness of various treatment modalities for keloids.
We assessed treatment outcomes in a cohort of 250 patients diagnosed with keloids. The patients were categorized into four treatment groups: triamcinolone acetonide (TA), TA + cryotherapy, TA + pulsed dye laser (PDL), and TA + cryotherapy + PDL. The Vancouver Scar Scale was used to evaluate the keloid severity before and after treatment.
Significant differences were noted in the Vancouver Scale scores among the treatment groups (=0.023). Notably, the TA + cryotherapy + PDL group exhibited the most substantial improvement in the Vancouver Scale scores, whereas the TA + PDL group showed the least difference. Pliability was the most significantly improved in the TA + cryotherapy + PDL group (=0.039). Male patients experienced a greater reduction in pigmentation scores than female patients (=0.037).
Our findings highlight the effectiveness of combined therapies, particularly TA + cryotherapy + PDL, in improving keloid-related parameters. These results offer valuable insights for clinicians in tailoring keloid treatment strategies and support the implementation of combination therapies for enhanced outcomes. This study underscores the importance of comprehensively assessing treatment modalities for keloid management. Combination therapies such as TA + cryotherapy + PDL irradiation have demonstrated significant promise in improving keloid characteristics.
多种治疗方式用于治疗瘢痕疙瘩。然而，有必要就患者报告的结果对这些治疗方式的有效性进行全面评估。
评估和比较多种治疗方式对瘢痕疙瘩的有效性。
我们评估了250例诊断为瘢痕疙瘩患者的治疗结果。患者被分为四个治疗组：曲安奈德（TA）、TA+冷冻疗法、TA+脉冲染料激光（PDL）以及TA+冷冻疗法+PDL。使用温哥华瘢痕量表评估治疗前后瘢痕疙瘩的严重程度。
各治疗组之间温哥华量表评分存在显著差异（=0.023）。值得注意的是，TA+冷冻疗法+PDL组在温哥华量表评分上改善最为显著，而TA+PDL组差异最小。TA+冷冻疗法+PDL组的柔韧性改善最为显著（=0.039）。男性患者色素沉着评分的降低幅度大于女性患者（=0.037）。
我们的研究结果突出了联合治疗，尤其是TA+冷冻疗法+PDL，在改善瘢痕疙瘩相关参数方面的有效性。这些结果为临床医生制定瘢痕疙瘩治疗策略提供了有价值的见解，并支持采用联合治疗以提高疗效。本研究强调了全面评估瘢痕疙瘩治疗方式的重要性。诸如TA+冷冻疗法+PDL照射等联合治疗在改善瘢痕疙瘩特征方面已显示出显著前景。
