Lu Yang-Jia, Cai Xiao-Wen, Zhang Gui-Feng, Huang Yong, Tang Chun-Zhi, Shan Bao-Ci, Cui Shao-Yang, Chen Jun-Qi, Qu Shan-Shan, Zhong Zheng, Lai Xin-Sheng, Steiner Genevieve Zara
School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong Province, China.
Traditional Chinese Medicine of the Second Clinical School, Guangdong Medical College, Dongguan, Guangdong Province, China.
Neural Regen Res. 2017 Jul;12(7):1159-1165. doi: 10.4103/1673-5374.211197.
The acute effect of acupuncture on Alzheimer's disease, ., on brain activation during treatment, has been reported. However, the effect of long-term acupuncture on brain activation in Alzheimer's disease is unclear. Therefore, in this study, we performed long-term needling at (ST36) or a sham point (1.5 mm lateral to ST36) in a rat Alzheimer's disease model, for 30 minutes, once per day, for 30 days. The rats underwent F-fluorodeoxyglucose positron emission tomography scanning. Positron emission tomography images were processed with SPM2. The brain areas activated after needling at ST36 included the left hippocampus, the left orbital cortex, the left infralimbic cortex, the left olfactory cortex, the left cerebellum and the left pons. In the sham-point group, the activated regions were similar to those in the ST36 group. However, the ST36 group showed greater activation in the cerebellum and pons than the sham-point group. These findings suggest that long-term acupuncture treatment has targeted regulatory effects on multiple brain regions in rats with Alzheimer's disease.
针刺对阿尔茨海默病的急性效应，即治疗期间对大脑激活的影响，已有报道。然而，长期针刺对阿尔茨海默病大脑激活的影响尚不清楚。因此，在本研究中，我们在大鼠阿尔茨海默病模型的足三里穴（ST36）或假穴（ST36外侧1.5毫米处）进行长期针刺，每次30分钟，每天1次，共30天。对大鼠进行F-氟脱氧葡萄糖正电子发射断层扫描。正电子发射断层扫描图像用SPM2进行处理。针刺足三里穴后激活的脑区包括左侧海马、左侧眶额皮质、左侧缘下皮质、左侧嗅觉皮质、左侧小脑和左侧脑桥。在假穴组中，激活区域与足三里穴组相似。然而，足三里穴组在小脑和脑桥的激活程度高于假穴组。这些发现表明，长期针刺治疗对阿尔茨海默病大鼠的多个脑区具有靶向调节作用。
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