稳定期镰状细胞贫血患儿微量白蛋白尿的患病率及影响因素
Prevalence and determinants of microalbuminuria in children suffering from sickle cell anemia in steady state.
作者信息
Aloni Michel N, Mabidi Jean-Louis L, Ngiyulu René M, Ekulu Pépé M, Mbutiwi Fiston I, Makulo Jean Robert, Sumaili Ernest K, Gini-Ehungu Jean Lambert, Nsibu Célestin N, Nseka Nazaire M, Lepira François B
机构信息
Division of Hemato-oncology and Nephrology, Department of Pediatrics, University Hospital of Kinshasa, School of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of Congo.
Division of Nephrology and Dialysis, Department of Internal Medicine, University Hospital of Kinshasa, School of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of Congo.
出版信息
Clin Kidney J. 2017 Aug;10(4):479-486. doi: 10.1093/ckj/sfx058. Epub 2017 Jul 12.
BACKGROUND
Sickle cell anemia (SCA) is considered a major risk factor for renal complications. The main goal of this study was to determine the frequency of macroalbuminuria and microalbuminuria in Congolese children <18 years of age suffering from Sickle cell anemia and to identify associated factors.
METHODS
The cross-sectional study was completed in 150 hemoglobin-SS children (77 boys and 73 girls). Microalbuminuria was defined by a urine albumin:creatinine ratio of 30-299 mg/g.
RESULTS
The mean age of this group was 8.8 ± 4.3 years (range 2-18). Microalbuminuria was found in 27 children (18%). In multivariate logistic regression, only age emerged as a determinant of microalbuminuria odds ratio 1.11 (95% confidence interval 1.00-1.22); P = 0.042].
CONCLUSIONS
In our series, only age was a major determinant of the occurrence of microalbuminuria. These results confirm the need for early screening of microalbuminuria in Congolese children suffering from Sickle cell anemia in a context where access to renal and bone marrow transplant is nonexistent.
背景
镰状细胞贫血（SCA）被认为是肾脏并发症的主要危险因素。本研究的主要目的是确定18岁以下患有镰状细胞贫血的刚果儿童中大量蛋白尿和微量蛋白尿的发生率，并确定相关因素。
方法
对150名血红蛋白SS型儿童（77名男孩和73名女孩）完成了横断面研究。微量蛋白尿的定义为尿白蛋白：肌酐比值为30 - 299mg/g。
结果
该组儿童的平均年龄为8.8±4.3岁（范围2 - 18岁）。27名儿童（18%）发现有微量蛋白尿。在多因素逻辑回归分析中，只有年龄是微量蛋白尿比值比的决定因素，为1.11（95%置信区间1.00 - 1.22）；P = 0.042]。
结论
在我们的研究系列中，只有年龄是微量蛋白尿发生的主要决定因素。这些结果证实了在刚果患有镰状细胞贫血的儿童无法获得肾脏和骨髓移植的情况下，有必要对微量蛋白尿进行早期筛查。
Zotero 插件