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一名年轻孕妇的罕见颈部肿瘤：诊断挑战与治疗反应

An unusual neck tumor in a young pregnant woman: challenge diagnosis and response to treatment.

作者信息

Arango Juan F, López Juan C, Arrazubi Virginia, Cisneros Silvia, Rodríguez Angel, Zabala Aitor, Martinez Del Prado Purificación

机构信息

Department of Medical Oncology, Hospital Universitario Basurto, Bilbao, Spain.

Department of Pathology, Hospital Universitario Basurto, Bilbao, Spain.

出版信息

Oxf Med Case Reports. 2017 Aug 2;2017(8):omx039. doi: 10.1093/omcr/omx039. eCollection 2017 Aug.

DOI:10.1093/omcr/omx039
PMID:28852532
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5569942/
Abstract

We report the case of a 19-year-old woman 33 weeks pregnant who presented a painful mass of progressive growth in the neck, having also dysphonia and dyspnea. Physical examination revealed a primary laryngeal tumor. A neuroendocrine small-cell carcinoma was diagnosed after histopathology, immunohistochemistry and genetic studies. Chemo-radiotherapy with a cisplatin-etoposide schedule was administered. Despite obtaining a complete response, the patient relapsed and finally survived 35 months with successive cisplatin-based treatments. Small-cell neuroendocrine carcinoma of the larynx is an uncommon entity, differential diagnosis can be problematic and treatment is challenging.

摘要

我们报告了一例19岁、孕33周的女性病例，该患者颈部出现一个进行性生长的疼痛性肿块，伴有声音嘶哑和呼吸困难。体格检查发现原发性喉部肿瘤。经组织病理学、免疫组织化学和基因研究后诊断为神经内分泌小细胞癌。采用顺铂-依托泊苷方案进行了放化疗。尽管获得了完全缓解，但患者复发，最终在连续的基于顺铂的治疗下存活了35个月。喉小细胞神经内分泌癌是一种罕见的疾病，鉴别诊断可能存在问题，治疗也具有挑战性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea5/5569942/57a42f464a85/omx039f05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea5/5569942/69e292ae9c08/omx039f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea5/5569942/d8d350bc855f/omx039f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea5/5569942/ea5d4865605c/omx039f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea5/5569942/eafe8b5b2d69/omx039f04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea5/5569942/57a42f464a85/omx039f05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea5/5569942/69e292ae9c08/omx039f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea5/5569942/d8d350bc855f/omx039f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea5/5569942/ea5d4865605c/omx039f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea5/5569942/eafe8b5b2d69/omx039f04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ea5/5569942/57a42f464a85/omx039f05.jpg

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