Meinck H-M
Neurologische Klinik, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Deutschland.
Nervenarzt. 2017 Oct;88(10):1133-1140. doi: 10.1007/s00115-017-0399-7.
Myoclonus is often a diagnostic and therapeutic challenge due to its broad phenomenological variability and limited therapeutic options. This article gives a short survey and characterizes in detail two common types of myoclonus, cortical myoclonus and reticular reflex myoclonus. Clinical testing and electrophysiological investigations provide relevant local diagnostic indications for the generating structure(s). Such indications would influence not only the strategies of neuroimaging and laboratory investigations aimed at clarifying the underlying cause but also the selection of drugs to suppress myoclonus.
肌阵挛常常是一个诊断和治疗难题,因为其临床表现具有广泛的变异性且治疗选择有限。本文进行了简要概述,并详细描述了两种常见的肌阵挛类型,即皮质肌阵挛和网状反射性肌阵挛。临床检查和电生理研究为产生肌阵挛的结构提供了相关的定位诊断依据。这些依据不仅会影响旨在明确潜在病因的神经影像学和实验室检查策略,还会影响抑制肌阵挛药物的选择。