Shibasaki H
Departments of Neurology and Brain Pathophysiology, Kyoto University School of Medicine, Shogoin, Sakyo, Kyoto, 606-8507 Japan.
Muscle Nerve. 2000 Mar;23(3):321-35. doi: 10.1002/(sici)1097-4598(200003)23:3<321::aid-mus3>3.0.co;2-3.
As myoclonus is often associated with abnormally increased excitability of cortical structures, electrophysiological studies provide useful information for its diagnosis and classification and about its generator mechanisms. The EEG-EMG polygraph provides the most essential information about the myoclonus of interest. Jerk-locked back averaging and evoked potential studies combined with recording of the long latency, long loop reflexes are useful to further investigate the pathophysiology of myoclonus, especially that of cortical myoclonus. A recent advance in magnetoencephalographic techniques has contributed significantly to the elucidation of some of the cortical mechanisms underlying myoclonus. Elucidation of physiological mechanisms underlying myoclonus in each individual patient is important for selecting the most appropriate treatment of choice.
由于肌阵挛常与皮质结构兴奋性异常增高相关，电生理研究为其诊断、分类及产生机制提供了有用信息。脑电图 - 肌电图多导记录图提供了有关所关注肌阵挛的最重要信息。急跳锁定反向平均法和诱发电位研究结合长潜伏期、长环反射的记录，有助于进一步研究肌阵挛的病理生理学，尤其是皮质肌阵挛的病理生理学。脑磁图技术的最新进展对阐明肌阵挛背后的一些皮质机制有显著贡献。阐明每个患者肌阵挛的生理机制对于选择最合适的治疗方法很重要。
