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肿瘤细胞谱系仅仅由机械力塑造吗？

Are Tumor Cell Lineages Solely Shaped by Mechanical Forces?

机构信息

Institut de Mathématiques de Toulouse, Université de Toulouse, CNRS, UPS, Toulouse, France.

ITAV-USR3505, Université de Toulouse, CNRS, UPS, Toulouse, France.

出版信息

Bull Math Biol. 2017 Oct;79(10):2356-2393. doi: 10.1007/s11538-017-0333-y. Epub 2017 Aug 29.

DOI:10.1007/s11538-017-0333-y
PMID:28852950
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5597711/
Abstract

This paper investigates cell proliferation dynamics in small tumor cell aggregates using an individual-based model (IBM). The simulation model is designed to study the morphology of the cell population and of the cell lineages as well as the impact of the orientation of the division plane on this morphology. Our IBM model is based on the hypothesis that cells are incompressible objects that grow in size and divide once a threshold size is reached, and that newly born cell adhere to the existing cell cluster. We performed comparisons between the simulation model and experimental data by using several statistical indicators. The results suggest that the emergence of particular morphologies can be explained by simple mechanical interactions.

摘要

本文使用基于个体的模型（IBM）研究了小肿瘤细胞聚集体中的细胞增殖动态。该仿真模型旨在研究细胞群体和细胞谱系的形态，以及分裂面的方向对这种形态的影响。我们的 IBM 模型基于以下假设：细胞是不可压缩的物体，它们在达到一定大小后会生长并分裂一次，并且新出生的细胞会附着在现有的细胞簇上。我们使用几个统计指标对模拟模型和实验数据进行了比较。结果表明，特定形态的出现可以用简单的力学相互作用来解释。

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2
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