Fomenko E V, Bobyntsev I I, Kryukov A A, Ivanov A V, Andreeva L A, Myasoedov N F
Department of Histology, Embryology and Cytology, Kursk, Russia.
Department of Physiology, Research Institute of General Pathology, Kursk State Medical University, Kursk, Russia.
Bull Exp Biol Med. 2017 Aug;163(4):415-418. doi: 10.1007/s10517-017-3817-8. Epub 2017 Aug 29.
We studied the effect of Selank administered intraperitoneally in doses of 100, 300, and 1000 μg/kg to male Wistar rats 15 min prior to restraint stress on the content of aminotransferases and total protein concentration in blood serum and intensity of free radical oxidation in the liver. Under conditions of acute restraint stress, Selank in doses of 100 and 300 μg/kg decreased catalase and superoxide dismutase activities and malondialdehyde concentration and increased total antioxidant activity in the liver homogenate. Administration of Selank in a dose of 1000 μg/kg reduced the content of aminotransferases in blood serum, decreased superoxide dismutase activity in the liver, and increased total antioxidant activity. Under conditions of chronic stress, Selank in all doses produced similar effects: reduced superoxide dismutase activity and malondialdehyde concentration in the liver tissue and AST activity in the serum. The other parameters remained unchanged.
我们研究了在束缚应激前15分钟，以100、300和1000μg/kg的剂量腹腔注射Selank对雄性Wistar大鼠血清中氨基转移酶含量、总蛋白浓度以及肝脏中自由基氧化强度的影响。在急性束缚应激条件下，100和300μg/kg剂量的Selank降低了肝脏匀浆中过氧化氢酶和超氧化物歧化酶的活性以及丙二醛浓度，并增加了总抗氧化活性。1000μg/kg剂量的Selank降低了血清中氨基转移酶的含量，降低了肝脏中超氧化物歧化酶的活性，并增加了总抗氧化活性。在慢性应激条件下，所有剂量的Selank都产生了类似的效果：降低了肝脏组织中超氧化物歧化酶的活性和丙二醛浓度以及血清中天冬氨酸转氨酶的活性。其他参数保持不变。
