Fomenko E V, Bobyntsev I I, Ivanov A V, Belykh A E, Andreeva L A, Myasoedov N F
Department of Histology, Cytology, and Embryology, Moscow, Russia.
Department of Pathophysiology, Moscow, Russia.
Bull Exp Biol Med. 2019 Jun;167(2):293-296. doi: 10.1007/s10517-019-04512-1. Epub 2019 Jun 26.
We studied the effects of Selank on morphological parameters of the liver in Wistar male rats subjected to chronic foot-shock stress. Selank was injected intraperitoneally in doses of 100, 300 and 1000 μg/kg 15 min before each stress session. Morphological and morphometrical analysis showed that chronic foot-shock stress induced hydropic degeneration of hepatocytes, an increase of the nucleus/cytoplasm ratio due to an increase in the area of nuclei and reduction of the cytoplasm area, the appearance of focal necroses, and lymphohistiocyte infiltration. Injection of Selank in all doses reduced the intensity of stress-induced degenerative changes. Administration of Selank in doses of 300 and 1000 μg/kg restored the nucleus/cytoplasm ratio in hepatocytes. The maximum stress-limiting effect was attained after administration of 300 μg/kg Selank.
我们研究了塞来昔布对遭受慢性足部电击应激的雄性Wistar大鼠肝脏形态学参数的影响。在每次应激实验前15分钟，以100、300和1000μg/kg的剂量腹腔注射塞来昔布。形态学和形态计量学分析表明，慢性足部电击应激可诱导肝细胞水样变性，由于细胞核面积增加和细胞质面积减少导致核质比增加，出现局灶性坏死以及淋巴细胞-组织细胞浸润。所有剂量的塞来昔布注射均降低了应激诱导的退行性变化的强度。以300和1000μg/kg的剂量给予塞来昔布可恢复肝细胞的核质比。给予300μg/kg塞来昔布后达到最大的应激限制效果。
